Research

Two ways of scheduling gum treatment gave similar results

19.07.18

Periodontal treatment can be delivered over a short period or spread across several visits. Both schedules improved gum health.

Tiny genetic signals in gum fluid may help future testing

15.05.18

MicroRNAs are small molecules that help regulate how cells use genetic information. The markers were higher with periodontitis and decreased after treatment.

Blood glucose and bacteria beneath the gums

09.05.18

Bacteria beneath the gumline live as a community, and their surroundings may be affected by diabetes. Some bacterial community patterns differed between the groups.

Green tea and gum damage in diabetic rats

16.04.18

Researchers are investigating whether substances in green tea influence inflammation and the small blood vessels around teeth. Diabetic rats receiving green tea developed less periodontal damage than diabetic rats receiving water.

Gum disease and gestational diabetes in a pregnancy cohort

03.04.18

Pregnancy can involve changes in both gums and glucose regulation. Gestational diabetes was more common in women with periodontitis than in those with healthy gums.

Inflammation may help explain links between gums and blood glucose

03.03.18

Inflammation is one possible connection between periodontitis and glucose regulation. More severe periodontitis was associated with raised glucose and diabetes.

Gum disease and small blood vessels at the back of the eye

31.01.18

Photographs of the retina can show small blood vessels and offer clues about vascular health. Some retinal vessel measurements were associated with severe periodontitis in men, but not women.

Signals from bone cells may help explain gum damage in diabetes

25.01.18

Bone is constantly renewed through a balance of formation and removal. Ordinary diabetic mice had more periodontal bone loss than their non-diabetic counterparts.

Diabetes, smoking and signals that may slow bone repair

12.01.18

The body uses signals that either encourage or restrain bone formation. Several proteins related to inflammation or inhibition of bone formation were higher in groups with diabetes, smoking or both.

EFP–IDF evidence update: understanding the gum disease–diabetes link

26.12.17

The European Federation of Periodontology and International Diabetes Federation have examined evidence connecting gum disease with diabetes. Overall, periodontitis was associated with higher glucose measures and a greater frequency of prediabetes or later diabetes in several studies.

One-stage versus quadrant-by-quadrant non-surgical periodontal therapy in type 2 diabetes

19.07.18

Patients with type 2 diabetes mellitus (T2DM) exhibit higher prevalence and severity of chronic periodontitis compared to individuals without diabetes.
Non-surgical periodontal therapy (NSPT), including scaling and root planing (SRP), has been suggested to improve glycaemic control in T2DM patients.

MicroRNA biomarkers for periodontitis with and without diabetes

15.05.18

This study investigated whether 2 microRNAs in gingival crevicular fluid could help identify periodontitis in people with and without type 2 diabetes. Both markers were elevated in periodontitis and decreased after non-surgical treatment, suggesting potential roles in disease assessment and monitoring treatment response.

Impact of glycaemic status on the subgingival microbiome in diabetes

09.05.18

The human microbiome plays a vital role in health, with links between gut microbiota and metabolic disorders like type 2 diabetes mellitus (T2DM).The oral microbiota, particularly the subgingival microbiome, is thought to be influenced by diabetes.

Green tea, periodontal blood vessels and diabetes-related bone loss

16.04.18

This animal study investigated whether green tea could protect periodontal tissues during prolonged hyperglycaemia in rats with type 1 diabetes. Green tea consumption preserved measures of the small blood vessel network and reduced periodontal destruction, although it did not completely prevent disease.

Periodontal disease and gestational diabetes: a prospective cohort study

03.04.18

Gestational diabetes mellitus (GDM) is a carbohydrate intolerance which begins during pregnancy, with Indian women at significantly higher risk (approximately 11-fold) compared to Caucasians.

Analysis of systemic inflammation on the link between periodontitis and glycaemic status

03.03.18

• Emerging evidence suggests that periodontitis may increase the risk of developing type 2 diabetes.
• Cross-sectional studies, such as NHANES III in the US and KNHANES in Korea, have shown that periodontitis is associated with impaired fasting glucose and diabetes.
• Prospective studies in the US, Germany, and Japan further confirmed that individuals with periodontitis have poorer glycaemic control and higher risk of diabetes.

Periodontitis and retinal vessel health

31.01.18

Chronic periodontitis is a common inflammatory disease that causes progressive bone loss and, if untreated, can lead to tooth loss.

Osteocyte signalling and periodontal bone loss in diabetes

25.01.18

This experimental study investigated how osteocytes (cells embedded within bone) contribute to periodontal bone loss in mice with and without diabetes. Deleting their production of RANKL (a signal that promotes bone breakdown) prevented significant infection-induced bone loss in both groups.

Diabetes, smoking and inhibitors of periodontal bone formation

12.01.18

This human study investigated whether diabetes and smoking were associated with increased levels of proteins that inhibit bone formation in people with periodontitis. Both risk factors were linked to changes in sclerostin and DKK1, suggesting a possible mechanism through which periodontal bone maintenance and repair may be impaired.

Periodontitis and diabetes: An EFP–IDF evidence update on risk, control and complications

26.12.17

This systematic review examined whether periodontitis was associated with poorer blood glucose control, development of type 2 diabetes and diabetes-related complications. The evidence generally supported these associations, although differences in study quality and methods limited the strength of the conclusions.