Welcome to the Research Hub – your go-to source for concise, digestible summaries of the latest research on the connection between periodontitis and diabetes. Explore key findings on topics such as how periodontal inflammation affects glycaemic control and the benefits of periodontal treatment.
Our summaries provide quick insights, but they are not exhaustive. For a complete understanding of each study’s methodology, results, and implications, we encourage you to review the original research articles. Please note that the Periodontitis-Diabetes hub is not responsible for inaccuracies or misinterpretations of condensed content.
For more guidance on understanding research, including how to interpret studies and evaluate their findings, visit the Colgate StuDENT App 
and search for ‘Understanding Research in Dentistry.’
Dive into the science and uncover the powerful link between oral and systemic health!
Type 2 diabetes mellitus (T2DM) is a growing global health issue, with millions remaining undiagnosed.In Singapore, diabetes prevalence is among the highest in Southeast Asia, with half of those affected unaware of their condition at diagnosis.
Read more
Periodontitis affects up to 45% of adults in the United States (US) and has been significantly associated with various systemic health conditions such as diabetes and cardiovascular disease. Current research suggests that periodontal disease may not only impact oral health but also influence overall mortality.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Periodontal disease is commonly seen in individuals with diabetes, particularly with Type 2 diabetes mellitus (T2DM). The chronic inflammation associated with periodontal disease can exacerbate glycaemic control issues and contribute to the progression of diabetes. There is increased evidence regarding the bidirectional relationship between periodontitis and diabetes. Poor glycaemic control can worsen periodontal health, while periodontitis can further impair glycaemic control, creating a vicious cycle.
Read more
Type 2 diabetes mellitus (T2DM) is a metabolic condition characterised by elevated blood sugar levels due to insufficient insulin function. Effective glycaemic control is crucial for minimising the risk of both microvascular and macrovascular complications. Research indicates that even a 1% reduction in HbA1c levels can significantly lower the incidence of related health issues.
Read more
Prediabetes is increasingly recognised as a major public health issue, affecting about 35% of adults in the United States (US), or roughly 88 million people. While it serves as a significant indicator for developing diabetes, prediabetes is reversible, with around 13% of individuals returning to normal glucose levels. Managing risk factors during the prediabetic phase could alleviate the diabetes burden, a leading cause of morbidity and mortality.
Read more
Periodontal breakdown can lead to further damage in nearby tissues if not treated adequately. Extracting a hopeless or non-essential adjacent tooth can enhance the survival of molars that have undergone periodontal treatment.
Read more
Diabetes mellitus (DM) has associated complications, ranging from cardiovascular issues to kidney diseases, which impose a considerable burden on both those living with diabetes and the healthcare system at large. Effective management of blood sugar levels is pivotal in averting these complications and enhancing the overall outlook for individuals with diabetes.
Read more
Diabetes mellitus (DM) is a global health concern, affecting 537 million people worldwide and accounting for 10% of healthcare expenditure in developed countries.
Read more
Supportive periodontal care (SPC) is critical for maintaining periodontal stability and preventing recurrence of periodontitis. Personalising treatment plans is increasingly essential due to varying chronic illnesses and patient capacities. Periodontal breakdown during SPC often necessitates additional active therapy, highlighting the need for robust risk assessment tools.
Read more
Periodontitis, a chronic inflammatory disease affecting the supporting structures of the teeth, has been linked to various systemic health issues, including cardiovascular disease and diabetes. Given the increasing prevalence of both diabetes and periodontal disease, understanding their interplay is crucial for public health.
Read more
The study investigates the association between periodontal diseases and chronic obstructive pulmonary disease (COPD), motivated by emerging evidence suggesting a potential link between oral health and respiratory conditions.
Read more
The study represents a significant contribution to the understanding of long-term outcomes in periodontal treatment, specifically for patients diagnosed with stages III and IV periodontitis. With the ultimate goal of preserving natural teeth for life, the research addresses the critical need for comprehensive data on tooth loss and treatment efficacy over extended periods.
Read more
Diabetes mellitus (DM) is a significant risk factor for periodontal disease, characterised by hyperglycaemia, chronic inflammation, and compromised immune defence. Poorly controlled blood glucose levels increase the prevalence and severity of periodontal disease, impacting the quality of life for affected individuals. Recent research has introduced the concept of ‘inflamm-ageing’- a pro-inflammatory state linked to diabetes that exacerbates tissue damage through macrophage activation.
Read more
There is a well-established bidirectional relationship between periodontitis and diabetes. Individuals with poorly controlled diabetes are at a higher risk of developing periodontal disease due to the effects of hyperglycaemia on immune function and tissue healing. On the other hand, periodontal disease can exacerbate glycaemic control, leading to increased insulin resistance and worsening metabolic outcomes. The systemic inflammation associated with periodontal disease is believed to contribute to the pathophysiology of diabetes, as inflammatory mediators can interfere with insulin signalling pathways.<
Read more
Periodontal disease, a chronic inflammatory condition affecting the supporting structures of teeth, is prevalent among individuals with diabetes, who are often at a heightened risk due to compromised immune responses and metabolic dysregulation. Conversely, poor glycaemic control has been implicated in the progression of periodontal disease, suggesting a bidirectional relationship that warrants further investigation.
Read more
Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that can arise following dental implant placement. These conditions are characterised by inflammation of the peri-implant tissues, which can lead to implant failure if not managed effectively.
Read more
Periodontal treatment involves a stepwise framework, including non-surgical sub-gingival instrumentation as the cornerstone for managing periodontitis. This reduces gingival inflammation, probing pocket depth (PPD), and clinical attachment loss (CAL) while improving overall health and quality of life. However, non-surgical treatment can induce an acute-phase systemic inflammatory reaction post-operatively, including increased acute-phase proteins, endothelial dysfunction, elevated body temperature, clotting tendencies, and renal function reduction.
Read more
Metabolic syndrome (MetS) is a cluster of conditions—obesity, dyslipidemia, hypertension, and insulin resistance—that significantly increase the risk of diabetes and cardiovascular disease.Periodontitis, a chronic inflammatory disease of the gums, has been linked to systemic inflammation, insulin resistance, and worsening glycaemic control.
Read more
Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of teeth, which can lead to tooth loss and has been associated with various systemic diseases, including diabetes. The relationship between oral health and systemic conditions has garnered increasing attention, particularly as periodontal disease may influence metabolic processes. Previous studies have suggested that individuals with periodontal disease may have a higher risk of developing diabetes due to shared risk factors such as inflammation and insulin resistance.
Read more
Periodontitis, a chronic inflammatory condition, is a leading cause of tooth loss in adults and is exacerbated by diabetes-related hyperglycemia.Diabetes promotes periodontal inflammation and disrupts alveolar bone homeostasis, contributing to tissue damage. Alveolar bone homeostasis involves the endocrine system, signaling interactions between bone and immune cells, and mechanically loaded forces. It relies on bone-resorbing osteoclasts, bone-producing osteoblasts, their precursors and immunoregulatory mediators.
Read more
Diabetes mellitus (DM) is a chronic condition where the body fails to produce or effectively use insulin, resulting in elevated blood glucose. Poor glycaemic control in DM patients can lead to severe complications like cardiovascular disease and kidney failure. The glycosylated haemoglobin assay (HbA1c) is a reliable measure of long-term blood sugar control and is linked to the risk of diabetic complications.
Read more
Diabetes mellitus (DM) is a significant global health issue, often remaining undiagnosed during its asymptomatic phase. Timely detection can prevent complications. Given the bidirectional link between diabetes and periodontitis, dental professionals are uniquely positioned to identify undiagnosed hyperglycaemia using periodontal measures.
Read more
Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting tissues and eventual tooth loss if untreated. It is highly prevalent worldwide, affecting 10–60% of populations. Beyond oral health, periodontitis contributes to systemic diseases by allowing pathogens (bacteria) and inflammatory mediators to enter the circulatory system, increasing risks for conditions like diabetes mellitus (DM), cardiovascular diseases, and adverse pregnancy outcomes.
Read more
Tooth loss (TL), a significant outcome of periodontitis, affects patients physiologically and psychologically. Periodontal therapy and patient compliance during supportive periodontal care (SPC) are crucial in reducing TL risk.Studies highlight patient- and tooth-related factors influencing TL, including periodontal bone loss, tooth mobility, furcation involvement (FI), tooth type, and vitality, with FI identified as a major predictor of molar survival.
Read more
Periodontitis (gum disease) is a chronic inflammatory condition affecting the tissues that support teeth. It has been associated with systemic conditions like cardiovascular disease and diabetes.
Read more
Periodontitis is a chronic inflammatory condition that causes gum and bone damage. It is often linked with systemic inflammation and conditions like metabolic syndrome (MetS).
Read more
Diabetes mellitus (DM) accelerates periodontal disease through hyperglycaemia-induced inflamm-ageing, a chronic, low-grade inflammatory state driven by cellular senescence and the senescence-associated secretory phenotype (SASP). Inflamm-aging disrupts gingival defence mechanisms, including epithelial and fibroblast resistance and immune responses to infection.
Read more
Periodontal maintenance (PM) is crucial for preventing the progression of periodontitis and minimising tooth loss after active periodontal treatment (APT). It includes tailored care such as oral hygiene education, scaling, root planing, and tooth polishing. Despite advances in periodontal therapy, factors like age, smoking, diabetes, and compliance with PM visits impact treatment outcomes.
Read more
Periodontitis is a chronic inflammatory disease causing tissue destruction and tooth loss, often requiring lifelong management. Regular maintenance, termed supportive periodontal therapy (SPT), plays a crucial role in preventing disease progression. The World Workshop (2017) introduced a multidimensional classification for periodontitis, categorising cases into stages (severity) and grades (rate of progression). This study aims to evaluate how the regularity of maintenance visits impacts tooth loss related to periodontitis (TLP) based on staging and grading. It hypothesises that higher disease severity (stages III/IV) and rapid progression (grade C) increase susceptibility to tooth loss, especially with inconsistent maintenance.
Read more
Periodontitis and type 2 diabetes are linked through a bidirectional relationship: diabetes increases the risk and severity of periodontitis, while periodontal inflammation worsens glycaemic control.
Systemic inflammation, driven by cytokines, contributes to complications such as cardiovascular disease and stroke. Associations between severe periodontitis and cardiovascular diseases have also been well-established.
Diabetes mellitus (DM) is a prevalent chronic condition, often undiagnosed, and associated with significant morbidity. Periodontitis is a chronic gum disease linked to systemic inflammation, and dental settings have been proposed as a location for screening undiagnosed DM and prediabetes.
Read more
Periodontitis, a chronic gum disease, involves inflammation and tissue destruction. It is especially common in people living with diabetes, making diagnosis and monitoring crucial.
Read more
Periodontitis has been linked to various systemic diseases, including diabetes, cardiovascular disease, and rheumatoid arthriti
Read more
Partial-mouth protocols (PMPs) are commonly used in population health studies to estimate periodontal disease prevalence, offering a cost-effective and time-efficient alternative to full-mouth protocols (FMPs). However, PMPs are known to underestimate periodontal disease prevalence, which may lead to biases in studies examining associations between periodontitis and systemic conditions like diabetes and cardiovascular disease (CVD).
Read more
Periodontitis, a chronic inflammatory disease caused by bacterial plaque, is associated with systemic conditions such as cardiovascular diseases, diabetes, and adverse pregnancy outcomes. It has also been linked to increased mortality risks
Read more
Periodontal disease, affecting hundreds of millions adults globally, is a leading cause of tooth loss and negatively impacts oral health-related quality of life.
Read more
Inflammation plays a pivotal role in cardiovascular disease (CVD) progression, particularly in patients with diabetes mellitus (DM) and periodontitis, which share risk factors and systemic inflammatory pathways.
Read more
Periodontitis, affecting 11.2% globally, causes tissue destruction, tooth loss, and reduced quality of life. Its bidirectional link with type 2 diabetes mellitus (T2DM) is well-established, with diabetes increasing periodontitis risk and periodontitis worsening glycemic control.
Read more
Periodontitis progression is influenced by common risk factors, including poor oral hygiene, smoking, and lifestyle habits. Interventions targeting these factors can improve treatment outcomes and periodontal health.
Read more
Chronic kidney disease (CKD) involves impaired kidney function, increasing the risk of cardiovascular disease, infection, and mortality. Despite medical advances, CKD prevalence is rising globally.
Read more
Periodontitis and diabetes mellitus (DM) are closely linked, with DM being a significant risk factor for severe periodontitis. Conversely, periodontitis may exacerbate glycaemic management in people living wiith diabetes.
Non-surgical periodontal therapy is an effective treatment to reduce inflammation and improve periodontal health. However, there is uncertainty regarding how diabetes impacts the clinical response to periodontal treatment.
The global rise in type 2 diabetes is a significant contributor to disability and early mortality, often due to vascular and renal complications. Chronic inflammation affects glycaemic control in diabetes, linking it with cardiovascular and kidney diseases. Periodontitis, a prevalent inflammatory condition often co-existing with diabetes, involves an imbalance in oral bacteria and elicits a systemic inflammatory response, raising risks for severe conditions like cardiovascular disease and renal failure. Periodontal therapy aims to manage inflammation through dental cleaning, oral hygiene advice, and possible surgical intervention.
Read more
Diabetes mellitus (DM) is closely associated with periodontitis, with evidence suggesting a bidirectional relationship. While periodontitis may exacerbate systemic inflammation and insulin resistance, periodontal therapy is hypothesised to improve glycaemic management and reduce inflammation in people living with diabetes.
Read more
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterised by insulin resistance and elevated blood glucose levels, influenced by factors like obesity and inflammation.
Read more
Patients with type 2 diabetes mellitus (T2DM) exhibit higher prevalence and severity of chronic periodontitis compared to individuals without diabetes.
Non-surgical periodontal therapy (NSPT), including scaling and root planing (SRP), has been suggested to improve glycaemic control in T2DM patients.
The human microbiome plays a vital role in health, with links between gut microbiota and metabolic disorders like type 2 diabetes mellitus (T2DM).The oral microbiota, particularly the subgingival microbiome, is thought to be influenced by diabetes.
Read more
Gestational diabetes mellitus (GDM) is a carbohydrate intolerance which begins during pregnancy, with Indian women at significantly higher risk (approximately 11-fold) compared to Caucasians.
Read more
Chronic periodontitis is a common inflammatory disease that causes progressive bone loss and, if untreated, can lead to tooth loss.
Read more
Periodontitis is a widespread condition affecting over half of the global adult population, with prevalence increasing with age.Severe periodontitis is one of the most common human diseases, contributing significantly to tooth loss.
Read more
Diabetes mellitus (DM), particularly type 2 (T2DM), is prevalent in the elderly and associated with complications like neuropathy, retinopathy, and cardiovascular issues. Poor glycaemic management exacerbates these complications, significantly affecting quality of life. Periodontitis, a chronic inflammatory disease of the gums, is common in individuals with T2DM. Research indicates a two-way relationship: Periodontitis worsens gum health, while DM elevates systemic inflammation, impairing blood glucose control. In Japan, over half the population aged 40+ years experiences periodontitis. Addressing periodontitis could potentially improve glycaemic management in people with T2DM. This study aimed to assess whether dental visits for periodontal treatment correlate with improved diabetes outcomes in an elderly Japanese cohort.
Read more
There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM). Periodontal disease is more prevalent in those with T2DM and contributes to chronic inflammation, potentially raising HbA1c levels. Persistently high HbA1c can lead to severe complications such as cardiovascular disease, blindness, amputations, renal failure, and premature death.
Read more
Diabetes risk and insulin resistance are associated with chronic systemic inflammation, often exacerbated by microbial factors. Inflammation interferes with insulin signalling, increasing diabetes susceptibility. Periodontitis, a chronic infection of the tooth-supporting structures, is linked to systemic inflammation and glucose intolerance. Emerging research suggests that early microbial changes in the subgingival environment may play a pivotal role in insulin resistance. The study aimed to investigate the relationship between subgingival bacterial composition, systemic inflammation, and insulin resistance in individuals living without diabetes. The hypothesis posited that dysbiosis (bacterial imbalances) in the subgingival microbiome would correlate with elevated inflammation and insulin resistance markers and that systemic inflammation would mediate this relationship. By identifying specific microbial signatures linked to inflammation and glucose regulation, the study hoped to improve early detection of diabetes risks and inform future intervention strategies.
Read more
Chronic kidney disease (CKD) affects 8–13% of the global population and is linked to higher mortality, primarily from cardiovascular disease (CVD).Systemic inflammation is a key non-traditional risk factor in CKD.
Read more
Gestational diabetes mellitus (GDM) and periodontal inflammation are independently associated with adverse pregnancy outcomes, including preterm birth, preeclampsia, and low birth weight.
Read more
Diabetes mellitus (DM) is a significant global health challenge, with Type 2 diabete mellitus (T2DM) often going undiagnosed for years. It is estimated that 46% of diabetes cases worldwide remain undiagnosed, contributing to delayed treatment and increased complications.
Read more
Diabetes mellitus (DM) is a common condition linked to systemic and oral complications, including periodontitis, with evidence of a bidirectional relationship between the two.
Read more
Periodontitis, a chronic inflammatory condition affecting tooth-supporting structures, is increasingly recognised as influencing systemic health. Evidence links periodontitis with cardiovascular disease (CVD), atherosclerosis, and metabolic disorders, such as diabetes. The disease’s systemic effects may stem from persistent low-grade inflammation and the spread of oral bacteria and pro-inflammatory cytokines into circulation. Elevated markers like high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) are shared by periodontitis and atherosclerosis.
Read more
Inflammation plays a pivotal role in cardiovascular disease (CVD) progression, particularly in patients with diabetes mellitus (DM) and periodontitis, which share risk factors and systemic inflammatory pathways.
Read more
Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance and obesity, which increases the risk for cardiovascular diseases and type 2 diabetes. Its prevalence varies globally, influenced by factors such as gender, country, and ethnicity. In the United States, about 25% of adults over 20 and 40% of older adults are affected. In Europe, prevalence ranges from 7% to 36% in men and 5% to 22% in women, depending on the study and population. Rapid economic changes in countries like China have seen a rise in MetS, largely due to increasing obesity rates.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Type 1 Diabetes Mellitus (T1DM) is associated with systemic inflammation, which may worsen oral health. Periodontitis, a chronic inflammatory condition leading to gum and bone loss, has been linked to worse glycaemic control.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Periodontitis is a chronic inflammatory disease affecting tooth-supporting tissues, driven by pathogenic plaque biofilm and a hyper-inflammatory host response. It leads to periodontal pocket formation, tissue destruction, and potential tooth loss. Individuals with Type 2 diabetes face an increased risk and severity of periodontitis due to their predisposition to oxidative stress and inflammation.
Read more
Insulin resistance, a condition where cells fail to respond effectively to insulin, is central to metabolic disorders like type 2 diabetes and cardiovascular disease. It often leads to systemic low-grade inflammation, a feature shared with periodontal disease, suggesting a potential biological link between these conditions.
Read more
Periodontitis and diabetes share a bidirectional relationship, where poor glycaemic control exacerbates periodontal disease and vice versa. The interplay between periodontal inflammation and glycaemic status is mediated by immune cells, primarily T-helper (Th) cells, which regulate pro- and anti-inflammatory cytokine production.
Read more
Periodontal disease and type 2 diabetes mellitus (T2DM) are interrelated, with evidence suggesting that periodontal disease worsens diabetic control and, conversely, that managing periodontal disease can improve glycaemic control. The host inflammatory response plays a key role in increasing susceptibility to periodontal disease, particularly in individuals with systemic conditions like T2DM. Studies show that individuals with severe periodontitis experience more diabetes-related complications and have poorer HbA1c levels over time. The Gullah population of coastal South Carolina and Georgia, descendants of enslaved Africans, is particularly affected by T2DM due to their genetic predisposition and social isolation. The Gullah have a higher prevalence of chronic diseases, including obesity and hypertension, compared to other populations. Notably, periodontal disease is more prevalent among Gullah individuals with T2DM (70.6%) compared to national estimates for African Americans with diabetes (31.3%). This study aimed to explore the relationship between glycaemic control and periodontal disease progression in Gullah individuals with T2DM.
Read more
Diabetes poses a significant public health burden globally, with prevalence expected to rise sharply, especially in urbanizing areas of developing countries.
Read more
Periodontitis, an inflammatory disease causing tissue destruction of the tissues surrounding teeth, may influence systemic inflammation, particularly in individuals with diabetes.
Read more
Welcome to the Research Hub – your go-to source for concise, digestible summaries of the latest research on the connection between periodontitis and diabetes. Explore key findings on topics such as how periodontal inflammation affects glycaemic control and the benefits of periodontal treatment.
Our summaries provide quick insights, but they are not exhaustive. For a complete understanding of each study’s methodology, results, and implications, we encourage you to review the original research articles. Please note that the Periodontitis-Diabetes hub is not responsible for inaccuracies or misinterpretations of condensed content.
For more guidance on understanding research, including how to interpret studies and evaluate their findings, visit the Colgate StuDENT App and search for ‘Understanding Research in Dentistry.’
Dive into the science and uncover the powerful link between oral and systemic health!
Type 2 diabetes mellitus (T2DM) is a growing global health issue, with millions remaining undiagnosed.In Singapore, diabetes prevalence is among the highest in Southeast Asia, with half of those affected unaware of their condition at diagnosis.
Read more
Periodontitis affects up to 45% of adults in the United States (US) and has been significantly associated with various systemic health conditions such as diabetes and cardiovascular disease. Current research suggests that periodontal disease may not only impact oral health but also influence overall mortality.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Periodontal disease is commonly seen in individuals with diabetes, particularly with Type 2 diabetes mellitus (T2DM). The chronic inflammation associated with periodontal disease can exacerbate glycaemic control issues and contribute to the progression of diabetes. There is increased evidence regarding the bidirectional relationship between periodontitis and diabetes. Poor glycaemic control can worsen periodontal health, while periodontitis can further impair glycaemic control, creating a vicious cycle.
Read more
Type 2 diabetes mellitus (T2DM) is a metabolic condition characterised by elevated blood sugar levels due to insufficient insulin function. Effective glycaemic control is crucial for minimising the risk of both microvascular and macrovascular complications. Research indicates that even a 1% reduction in HbA1c levels can significantly lower the incidence of related health issues.
Read more
Prediabetes is increasingly recognised as a major public health issue, affecting about 35% of adults in the United States (US), or roughly 88 million people. While it serves as a significant indicator for developing diabetes, prediabetes is reversible, with around 13% of individuals returning to normal glucose levels. Managing risk factors during the prediabetic phase could alleviate the diabetes burden, a leading cause of morbidity and mortality.
Read more
Periodontal breakdown can lead to further damage in nearby tissues if not treated adequately. Extracting a hopeless or non-essential adjacent tooth can enhance the survival of molars that have undergone periodontal treatment.
Read more
Diabetes mellitus (DM) has associated complications, ranging from cardiovascular issues to kidney diseases, which impose a considerable burden on both those living with diabetes and the healthcare system at large. Effective management of blood sugar levels is pivotal in averting these complications and enhancing the overall outlook for individuals with diabetes.
Read more
Diabetes mellitus (DM) is a global health concern, affecting 537 million people worldwide and accounting for 10% of healthcare expenditure in developed countries.
Read more
Supportive periodontal care (SPC) is critical for maintaining periodontal stability and preventing recurrence of periodontitis. Personalising treatment plans is increasingly essential due to varying chronic illnesses and patient capacities. Periodontal breakdown during SPC often necessitates additional active therapy, highlighting the need for robust risk assessment tools.
Read more
Periodontitis, a chronic inflammatory disease affecting the supporting structures of the teeth, has been linked to various systemic health issues, including cardiovascular disease and diabetes. Given the increasing prevalence of both diabetes and periodontal disease, understanding their interplay is crucial for public health.
Read more
The study investigates the association between periodontal diseases and chronic obstructive pulmonary disease (COPD), motivated by emerging evidence suggesting a potential link between oral health and respiratory conditions.
Read more
The study represents a significant contribution to the understanding of long-term outcomes in periodontal treatment, specifically for patients diagnosed with stages III and IV periodontitis. With the ultimate goal of preserving natural teeth for life, the research addresses the critical need for comprehensive data on tooth loss and treatment efficacy over extended periods.
Read more
Diabetes mellitus (DM) is a significant risk factor for periodontal disease, characterised by hyperglycaemia, chronic inflammation, and compromised immune defence. Poorly controlled blood glucose levels increase the prevalence and severity of periodontal disease, impacting the quality of life for affected individuals. Recent research has introduced the concept of ‘inflamm-ageing’- a pro-inflammatory state linked to diabetes that exacerbates tissue damage through macrophage activation.
Read more
There is a well-established bidirectional relationship between periodontitis and diabetes. Individuals with poorly controlled diabetes are at a higher risk of developing periodontal disease due to the effects of hyperglycaemia on immune function and tissue healing. On the other hand, periodontal disease can exacerbate glycaemic control, leading to increased insulin resistance and worsening metabolic outcomes. The systemic inflammation associated with periodontal disease is believed to contribute to the pathophysiology of diabetes, as inflammatory mediators can interfere with insulin signalling pathways.<
Read more
Periodontal disease, a chronic inflammatory condition affecting the supporting structures of teeth, is prevalent among individuals with diabetes, who are often at a heightened risk due to compromised immune responses and metabolic dysregulation. Conversely, poor glycaemic control has been implicated in the progression of periodontal disease, suggesting a bidirectional relationship that warrants further investigation.
Read more
Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that can arise following dental implant placement. These conditions are characterised by inflammation of the peri-implant tissues, which can lead to implant failure if not managed effectively.
Read more
Periodontal treatment involves a stepwise framework, including non-surgical sub-gingival instrumentation as the cornerstone for managing periodontitis. This reduces gingival inflammation, probing pocket depth (PPD), and clinical attachment loss (CAL) while improving overall health and quality of life. However, non-surgical treatment can induce an acute-phase systemic inflammatory reaction post-operatively, including increased acute-phase proteins, endothelial dysfunction, elevated body temperature, clotting tendencies, and renal function reduction.
Read more
Metabolic syndrome (MetS) is a cluster of conditions—obesity, dyslipidemia, hypertension, and insulin resistance—that significantly increase the risk of diabetes and cardiovascular disease.Periodontitis, a chronic inflammatory disease of the gums, has been linked to systemic inflammation, insulin resistance, and worsening glycaemic control.
Read more
Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of teeth, which can lead to tooth loss and has been associated with various systemic diseases, including diabetes. The relationship between oral health and systemic conditions has garnered increasing attention, particularly as periodontal disease may influence metabolic processes. Previous studies have suggested that individuals with periodontal disease may have a higher risk of developing diabetes due to shared risk factors such as inflammation and insulin resistance.
Read more
Periodontitis, a chronic inflammatory condition, is a leading cause of tooth loss in adults and is exacerbated by diabetes-related hyperglycemia.Diabetes promotes periodontal inflammation and disrupts alveolar bone homeostasis, contributing to tissue damage. Alveolar bone homeostasis involves the endocrine system, signaling interactions between bone and immune cells, and mechanically loaded forces. It relies on bone-resorbing osteoclasts, bone-producing osteoblasts, their precursors and immunoregulatory mediators.
Read more
Diabetes mellitus (DM) is a chronic condition where the body fails to produce or effectively use insulin, resulting in elevated blood glucose. Poor glycaemic control in DM patients can lead to severe complications like cardiovascular disease and kidney failure. The glycosylated haemoglobin assay (HbA1c) is a reliable measure of long-term blood sugar control and is linked to the risk of diabetic complications.
Read more
Diabetes mellitus (DM) is a significant global health issue, often remaining undiagnosed during its asymptomatic phase. Timely detection can prevent complications. Given the bidirectional link between diabetes and periodontitis, dental professionals are uniquely positioned to identify undiagnosed hyperglycaemia using periodontal measures.
Read more
Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting tissues and eventual tooth loss if untreated. It is highly prevalent worldwide, affecting 10–60% of populations. Beyond oral health, periodontitis contributes to systemic diseases by allowing pathogens (bacteria) and inflammatory mediators to enter the circulatory system, increasing risks for conditions like diabetes mellitus (DM), cardiovascular diseases, and adverse pregnancy outcomes.
Read more
Tooth loss (TL), a significant outcome of periodontitis, affects patients physiologically and psychologically. Periodontal therapy and patient compliance during supportive periodontal care (SPC) are crucial in reducing TL risk.Studies highlight patient- and tooth-related factors influencing TL, including periodontal bone loss, tooth mobility, furcation involvement (FI), tooth type, and vitality, with FI identified as a major predictor of molar survival.
Read more
Periodontitis (gum disease) is a chronic inflammatory condition affecting the tissues that support teeth. It has been associated with systemic conditions like cardiovascular disease and diabetes.
Read more
Periodontitis is a chronic inflammatory condition that causes gum and bone damage. It is often linked with systemic inflammation and conditions like metabolic syndrome (MetS).
Read more
Diabetes mellitus (DM) accelerates periodontal disease through hyperglycaemia-induced inflamm-ageing, a chronic, low-grade inflammatory state driven by cellular senescence and the senescence-associated secretory phenotype (SASP). Inflamm-aging disrupts gingival defence mechanisms, including epithelial and fibroblast resistance and immune responses to infection.
Read more
Periodontal maintenance (PM) is crucial for preventing the progression of periodontitis and minimising tooth loss after active periodontal treatment (APT). It includes tailored care such as oral hygiene education, scaling, root planing, and tooth polishing. Despite advances in periodontal therapy, factors like age, smoking, diabetes, and compliance with PM visits impact treatment outcomes.
Read more
Periodontitis is a chronic inflammatory disease causing tissue destruction and tooth loss, often requiring lifelong management. Regular maintenance, termed supportive periodontal therapy (SPT), plays a crucial role in preventing disease progression. The World Workshop (2017) introduced a multidimensional classification for periodontitis, categorising cases into stages (severity) and grades (rate of progression). This study aims to evaluate how the regularity of maintenance visits impacts tooth loss related to periodontitis (TLP) based on staging and grading. It hypothesises that higher disease severity (stages III/IV) and rapid progression (grade C) increase susceptibility to tooth loss, especially with inconsistent maintenance.
Read more
Periodontitis and type 2 diabetes are linked through a bidirectional relationship: diabetes increases the risk and severity of periodontitis, while periodontal inflammation worsens glycaemic control.
Systemic inflammation, driven by cytokines, contributes to complications such as cardiovascular disease and stroke. Associations between severe periodontitis and cardiovascular diseases have also been well-established.
Diabetes mellitus (DM) is a prevalent chronic condition, often undiagnosed, and associated with significant morbidity. Periodontitis is a chronic gum disease linked to systemic inflammation, and dental settings have been proposed as a location for screening undiagnosed DM and prediabetes.
Read more
Periodontitis, a chronic gum disease, involves inflammation and tissue destruction. It is especially common in people living with diabetes, making diagnosis and monitoring crucial.
Read more
Periodontitis has been linked to various systemic diseases, including diabetes, cardiovascular disease, and rheumatoid arthriti
Read more
Partial-mouth protocols (PMPs) are commonly used in population health studies to estimate periodontal disease prevalence, offering a cost-effective and time-efficient alternative to full-mouth protocols (FMPs). However, PMPs are known to underestimate periodontal disease prevalence, which may lead to biases in studies examining associations between periodontitis and systemic conditions like diabetes and cardiovascular disease (CVD).
Read more
Periodontitis, a chronic inflammatory disease caused by bacterial plaque, is associated with systemic conditions such as cardiovascular diseases, diabetes, and adverse pregnancy outcomes. It has also been linked to increased mortality risks
Read more
Periodontal disease, affecting hundreds of millions adults globally, is a leading cause of tooth loss and negatively impacts oral health-related quality of life.
Read more
Inflammation plays a pivotal role in cardiovascular disease (CVD) progression, particularly in patients with diabetes mellitus (DM) and periodontitis, which share risk factors and systemic inflammatory pathways.
Read more
Periodontitis, affecting 11.2% globally, causes tissue destruction, tooth loss, and reduced quality of life. Its bidirectional link with type 2 diabetes mellitus (T2DM) is well-established, with diabetes increasing periodontitis risk and periodontitis worsening glycemic control.
Read more
Periodontitis progression is influenced by common risk factors, including poor oral hygiene, smoking, and lifestyle habits. Interventions targeting these factors can improve treatment outcomes and periodontal health.
Read more
Chronic kidney disease (CKD) involves impaired kidney function, increasing the risk of cardiovascular disease, infection, and mortality. Despite medical advances, CKD prevalence is rising globally.
Read more
Periodontitis and diabetes mellitus (DM) are closely linked, with DM being a significant risk factor for severe periodontitis. Conversely, periodontitis may exacerbate glycaemic management in people living wiith diabetes.
Non-surgical periodontal therapy is an effective treatment to reduce inflammation and improve periodontal health. However, there is uncertainty regarding how diabetes impacts the clinical response to periodontal treatment.
The global rise in type 2 diabetes is a significant contributor to disability and early mortality, often due to vascular and renal complications. Chronic inflammation affects glycaemic control in diabetes, linking it with cardiovascular and kidney diseases. Periodontitis, a prevalent inflammatory condition often co-existing with diabetes, involves an imbalance in oral bacteria and elicits a systemic inflammatory response, raising risks for severe conditions like cardiovascular disease and renal failure. Periodontal therapy aims to manage inflammation through dental cleaning, oral hygiene advice, and possible surgical intervention.
Read more
Diabetes mellitus (DM) is closely associated with periodontitis, with evidence suggesting a bidirectional relationship. While periodontitis may exacerbate systemic inflammation and insulin resistance, periodontal therapy is hypothesised to improve glycaemic management and reduce inflammation in people living with diabetes.
Read more
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterised by insulin resistance and elevated blood glucose levels, influenced by factors like obesity and inflammation.
Read more
Patients with type 2 diabetes mellitus (T2DM) exhibit higher prevalence and severity of chronic periodontitis compared to individuals without diabetes.
Non-surgical periodontal therapy (NSPT), including scaling and root planing (SRP), has been suggested to improve glycaemic control in T2DM patients.
The human microbiome plays a vital role in health, with links between gut microbiota and metabolic disorders like type 2 diabetes mellitus (T2DM).The oral microbiota, particularly the subgingival microbiome, is thought to be influenced by diabetes.
Read more
Gestational diabetes mellitus (GDM) is a carbohydrate intolerance which begins during pregnancy, with Indian women at significantly higher risk (approximately 11-fold) compared to Caucasians.
Read more
Chronic periodontitis is a common inflammatory disease that causes progressive bone loss and, if untreated, can lead to tooth loss.
Read more
Periodontitis is a widespread condition affecting over half of the global adult population, with prevalence increasing with age.Severe periodontitis is one of the most common human diseases, contributing significantly to tooth loss.
Read more
Diabetes mellitus (DM), particularly type 2 (T2DM), is prevalent in the elderly and associated with complications like neuropathy, retinopathy, and cardiovascular issues. Poor glycaemic management exacerbates these complications, significantly affecting quality of life. Periodontitis, a chronic inflammatory disease of the gums, is common in individuals with T2DM. Research indicates a two-way relationship: Periodontitis worsens gum health, while DM elevates systemic inflammation, impairing blood glucose control. In Japan, over half the population aged 40+ years experiences periodontitis. Addressing periodontitis could potentially improve glycaemic management in people with T2DM. This study aimed to assess whether dental visits for periodontal treatment correlate with improved diabetes outcomes in an elderly Japanese cohort.
Read more
There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM). Periodontal disease is more prevalent in those with T2DM and contributes to chronic inflammation, potentially raising HbA1c levels. Persistently high HbA1c can lead to severe complications such as cardiovascular disease, blindness, amputations, renal failure, and premature death.
Read more
Diabetes risk and insulin resistance are associated with chronic systemic inflammation, often exacerbated by microbial factors. Inflammation interferes with insulin signalling, increasing diabetes susceptibility. Periodontitis, a chronic infection of the tooth-supporting structures, is linked to systemic inflammation and glucose intolerance. Emerging research suggests that early microbial changes in the subgingival environment may play a pivotal role in insulin resistance. The study aimed to investigate the relationship between subgingival bacterial composition, systemic inflammation, and insulin resistance in individuals living without diabetes. The hypothesis posited that dysbiosis (bacterial imbalances) in the subgingival microbiome would correlate with elevated inflammation and insulin resistance markers and that systemic inflammation would mediate this relationship. By identifying specific microbial signatures linked to inflammation and glucose regulation, the study hoped to improve early detection of diabetes risks and inform future intervention strategies.
Read more
Chronic kidney disease (CKD) affects 8–13% of the global population and is linked to higher mortality, primarily from cardiovascular disease (CVD).Systemic inflammation is a key non-traditional risk factor in CKD.
Read more
Gestational diabetes mellitus (GDM) and periodontal inflammation are independently associated with adverse pregnancy outcomes, including preterm birth, preeclampsia, and low birth weight.
Read more
Diabetes mellitus (DM) is a significant global health challenge, with Type 2 diabete mellitus (T2DM) often going undiagnosed for years. It is estimated that 46% of diabetes cases worldwide remain undiagnosed, contributing to delayed treatment and increased complications.
Read more
Diabetes mellitus (DM) is a common condition linked to systemic and oral complications, including periodontitis, with evidence of a bidirectional relationship between the two.
Read more
Periodontitis, a chronic inflammatory condition affecting tooth-supporting structures, is increasingly recognised as influencing systemic health. Evidence links periodontitis with cardiovascular disease (CVD), atherosclerosis, and metabolic disorders, such as diabetes. The disease’s systemic effects may stem from persistent low-grade inflammation and the spread of oral bacteria and pro-inflammatory cytokines into circulation. Elevated markers like high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) are shared by periodontitis and atherosclerosis.
Read more
Inflammation plays a pivotal role in cardiovascular disease (CVD) progression, particularly in patients with diabetes mellitus (DM) and periodontitis, which share risk factors and systemic inflammatory pathways.
Read more
Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance and obesity, which increases the risk for cardiovascular diseases and type 2 diabetes. Its prevalence varies globally, influenced by factors such as gender, country, and ethnicity. In the United States, about 25% of adults over 20 and 40% of older adults are affected. In Europe, prevalence ranges from 7% to 36% in men and 5% to 22% in women, depending on the study and population. Rapid economic changes in countries like China have seen a rise in MetS, largely due to increasing obesity rates.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Type 1 Diabetes Mellitus (T1DM) is associated with systemic inflammation, which may worsen oral health. Periodontitis, a chronic inflammatory condition leading to gum and bone loss, has been linked to worse glycaemic control.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Periodontitis is a chronic inflammatory disease affecting tooth-supporting tissues, driven by pathogenic plaque biofilm and a hyper-inflammatory host response. It leads to periodontal pocket formation, tissue destruction, and potential tooth loss. Individuals with Type 2 diabetes face an increased risk and severity of periodontitis due to their predisposition to oxidative stress and inflammation.
Read more
Insulin resistance, a condition where cells fail to respond effectively to insulin, is central to metabolic disorders like type 2 diabetes and cardiovascular disease. It often leads to systemic low-grade inflammation, a feature shared with periodontal disease, suggesting a potential biological link between these conditions.
Read more
Periodontitis and diabetes share a bidirectional relationship, where poor glycaemic control exacerbates periodontal disease and vice versa. The interplay between periodontal inflammation and glycaemic status is mediated by immune cells, primarily T-helper (Th) cells, which regulate pro- and anti-inflammatory cytokine production.
Read more
Periodontal disease and type 2 diabetes mellitus (T2DM) are interrelated, with evidence suggesting that periodontal disease worsens diabetic control and, conversely, that managing periodontal disease can improve glycaemic control. The host inflammatory response plays a key role in increasing susceptibility to periodontal disease, particularly in individuals with systemic conditions like T2DM. Studies show that individuals with severe periodontitis experience more diabetes-related complications and have poorer HbA1c levels over time. The Gullah population of coastal South Carolina and Georgia, descendants of enslaved Africans, is particularly affected by T2DM due to their genetic predisposition and social isolation. The Gullah have a higher prevalence of chronic diseases, including obesity and hypertension, compared to other populations. Notably, periodontal disease is more prevalent among Gullah individuals with T2DM (70.6%) compared to national estimates for African Americans with diabetes (31.3%). This study aimed to explore the relationship between glycaemic control and periodontal disease progression in Gullah individuals with T2DM.
Read more
Diabetes poses a significant public health burden globally, with prevalence expected to rise sharply, especially in urbanizing areas of developing countries.
Read more
Periodontitis, an inflammatory disease causing tissue destruction of the tissues surrounding teeth, may influence systemic inflammation, particularly in individuals with diabetes.
Read more
Welcome to the Research Hub – your go-to source for concise, digestible summaries of the latest research on the connection between periodontitis and diabetes. Explore key findings on topics such as how periodontal inflammation affects glycaemic control and the benefits of periodontal treatment.
Our summaries provide quick insights, but they are not exhaustive. For a complete understanding of each study’s methodology, results, and implications, we encourage you to review the original research articles. Please note that the Periodontitis-Diabetes hub is not responsible for inaccuracies or misinterpretations of condensed content.
For more guidance on understanding research, including how to interpret studies and evaluate their findings, visit the Colgate StuDENT App and search for ‘Understanding Research in Dentistry.’
Dive into the science and uncover the powerful link between oral and systemic health!
Type 2 diabetes mellitus (T2DM) is a growing global health issue, with millions remaining undiagnosed.In Singapore, diabetes prevalence is among the highest in Southeast Asia, with half of those affected unaware of their condition at diagnosis.
Read more
Periodontitis affects up to 45% of adults in the United States (US) and has been significantly associated with various systemic health conditions such as diabetes and cardiovascular disease. Current research suggests that periodontal disease may not only impact oral health but also influence overall mortality.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Periodontal disease is commonly seen in individuals with diabetes, particularly with Type 2 diabetes mellitus (T2DM). The chronic inflammation associated with periodontal disease can exacerbate glycaemic control issues and contribute to the progression of diabetes. There is increased evidence regarding the bidirectional relationship between periodontitis and diabetes. Poor glycaemic control can worsen periodontal health, while periodontitis can further impair glycaemic control, creating a vicious cycle.
Read more
Type 2 diabetes mellitus (T2DM) is a metabolic condition characterised by elevated blood sugar levels due to insufficient insulin function. Effective glycaemic control is crucial for minimising the risk of both microvascular and macrovascular complications. Research indicates that even a 1% reduction in HbA1c levels can significantly lower the incidence of related health issues.
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Prediabetes is increasingly recognised as a major public health issue, affecting about 35% of adults in the United States (US), or roughly 88 million people. While it serves as a significant indicator for developing diabetes, prediabetes is reversible, with around 13% of individuals returning to normal glucose levels. Managing risk factors during the prediabetic phase could alleviate the diabetes burden, a leading cause of morbidity and mortality.
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Periodontal breakdown can lead to further damage in nearby tissues if not treated adequately. Extracting a hopeless or non-essential adjacent tooth can enhance the survival of molars that have undergone periodontal treatment.
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Diabetes mellitus (DM) has associated complications, ranging from cardiovascular issues to kidney diseases, which impose a considerable burden on both those living with diabetes and the healthcare system at large. Effective management of blood sugar levels is pivotal in averting these complications and enhancing the overall outlook for individuals with diabetes.
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Diabetes mellitus (DM) is a global health concern, affecting 537 million people worldwide and accounting for 10% of healthcare expenditure in developed countries.
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Supportive periodontal care (SPC) is critical for maintaining periodontal stability and preventing recurrence of periodontitis. Personalising treatment plans is increasingly essential due to varying chronic illnesses and patient capacities. Periodontal breakdown during SPC often necessitates additional active therapy, highlighting the need for robust risk assessment tools.
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Periodontitis, a chronic inflammatory disease affecting the supporting structures of the teeth, has been linked to various systemic health issues, including cardiovascular disease and diabetes. Given the increasing prevalence of both diabetes and periodontal disease, understanding their interplay is crucial for public health.
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The study investigates the association between periodontal diseases and chronic obstructive pulmonary disease (COPD), motivated by emerging evidence suggesting a potential link between oral health and respiratory conditions.
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The study represents a significant contribution to the understanding of long-term outcomes in periodontal treatment, specifically for patients diagnosed with stages III and IV periodontitis. With the ultimate goal of preserving natural teeth for life, the research addresses the critical need for comprehensive data on tooth loss and treatment efficacy over extended periods.
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Diabetes mellitus (DM) is a significant risk factor for periodontal disease, characterised by hyperglycaemia, chronic inflammation, and compromised immune defence. Poorly controlled blood glucose levels increase the prevalence and severity of periodontal disease, impacting the quality of life for affected individuals. Recent research has introduced the concept of ‘inflamm-ageing’- a pro-inflammatory state linked to diabetes that exacerbates tissue damage through macrophage activation.
Read more
There is a well-established bidirectional relationship between periodontitis and diabetes. Individuals with poorly controlled diabetes are at a higher risk of developing periodontal disease due to the effects of hyperglycaemia on immune function and tissue healing. On the other hand, periodontal disease can exacerbate glycaemic control, leading to increased insulin resistance and worsening metabolic outcomes. The systemic inflammation associated with periodontal disease is believed to contribute to the pathophysiology of diabetes, as inflammatory mediators can interfere with insulin signalling pathways.<
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Periodontal disease, a chronic inflammatory condition affecting the supporting structures of teeth, is prevalent among individuals with diabetes, who are often at a heightened risk due to compromised immune responses and metabolic dysregulation. Conversely, poor glycaemic control has been implicated in the progression of periodontal disease, suggesting a bidirectional relationship that warrants further investigation.
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Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that can arise following dental implant placement. These conditions are characterised by inflammation of the peri-implant tissues, which can lead to implant failure if not managed effectively.
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Periodontal treatment involves a stepwise framework, including non-surgical sub-gingival instrumentation as the cornerstone for managing periodontitis. This reduces gingival inflammation, probing pocket depth (PPD), and clinical attachment loss (CAL) while improving overall health and quality of life. However, non-surgical treatment can induce an acute-phase systemic inflammatory reaction post-operatively, including increased acute-phase proteins, endothelial dysfunction, elevated body temperature, clotting tendencies, and renal function reduction.
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Metabolic syndrome (MetS) is a cluster of conditions—obesity, dyslipidemia, hypertension, and insulin resistance—that significantly increase the risk of diabetes and cardiovascular disease.Periodontitis, a chronic inflammatory disease of the gums, has been linked to systemic inflammation, insulin resistance, and worsening glycaemic control.
Read more
Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of teeth, which can lead to tooth loss and has been associated with various systemic diseases, including diabetes. The relationship between oral health and systemic conditions has garnered increasing attention, particularly as periodontal disease may influence metabolic processes. Previous studies have suggested that individuals with periodontal disease may have a higher risk of developing diabetes due to shared risk factors such as inflammation and insulin resistance.
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Periodontitis, a chronic inflammatory condition, is a leading cause of tooth loss in adults and is exacerbated by diabetes-related hyperglycemia.Diabetes promotes periodontal inflammation and disrupts alveolar bone homeostasis, contributing to tissue damage. Alveolar bone homeostasis involves the endocrine system, signaling interactions between bone and immune cells, and mechanically loaded forces. It relies on bone-resorbing osteoclasts, bone-producing osteoblasts, their precursors and immunoregulatory mediators.
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Diabetes mellitus (DM) is a chronic condition where the body fails to produce or effectively use insulin, resulting in elevated blood glucose. Poor glycaemic control in DM patients can lead to severe complications like cardiovascular disease and kidney failure. The glycosylated haemoglobin assay (HbA1c) is a reliable measure of long-term blood sugar control and is linked to the risk of diabetic complications.
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Diabetes mellitus (DM) is a significant global health issue, often remaining undiagnosed during its asymptomatic phase. Timely detection can prevent complications. Given the bidirectional link between diabetes and periodontitis, dental professionals are uniquely positioned to identify undiagnosed hyperglycaemia using periodontal measures.
Read more
Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting tissues and eventual tooth loss if untreated. It is highly prevalent worldwide, affecting 10–60% of populations. Beyond oral health, periodontitis contributes to systemic diseases by allowing pathogens (bacteria) and inflammatory mediators to enter the circulatory system, increasing risks for conditions like diabetes mellitus (DM), cardiovascular diseases, and adverse pregnancy outcomes.
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Tooth loss (TL), a significant outcome of periodontitis, affects patients physiologically and psychologically. Periodontal therapy and patient compliance during supportive periodontal care (SPC) are crucial in reducing TL risk.Studies highlight patient- and tooth-related factors influencing TL, including periodontal bone loss, tooth mobility, furcation involvement (FI), tooth type, and vitality, with FI identified as a major predictor of molar survival.
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Periodontitis (gum disease) is a chronic inflammatory condition affecting the tissues that support teeth. It has been associated with systemic conditions like cardiovascular disease and diabetes.
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Periodontitis is a chronic inflammatory condition that causes gum and bone damage. It is often linked with systemic inflammation and conditions like metabolic syndrome (MetS).
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Diabetes mellitus (DM) accelerates periodontal disease through hyperglycaemia-induced inflamm-ageing, a chronic, low-grade inflammatory state driven by cellular senescence and the senescence-associated secretory phenotype (SASP). Inflamm-aging disrupts gingival defence mechanisms, including epithelial and fibroblast resistance and immune responses to infection.
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Periodontal maintenance (PM) is crucial for preventing the progression of periodontitis and minimising tooth loss after active periodontal treatment (APT). It includes tailored care such as oral hygiene education, scaling, root planing, and tooth polishing. Despite advances in periodontal therapy, factors like age, smoking, diabetes, and compliance with PM visits impact treatment outcomes.
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Periodontitis is a chronic inflammatory disease causing tissue destruction and tooth loss, often requiring lifelong management. Regular maintenance, termed supportive periodontal therapy (SPT), plays a crucial role in preventing disease progression. The World Workshop (2017) introduced a multidimensional classification for periodontitis, categorising cases into stages (severity) and grades (rate of progression). This study aims to evaluate how the regularity of maintenance visits impacts tooth loss related to periodontitis (TLP) based on staging and grading. It hypothesises that higher disease severity (stages III/IV) and rapid progression (grade C) increase susceptibility to tooth loss, especially with inconsistent maintenance.
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Periodontitis and type 2 diabetes are linked through a bidirectional relationship: diabetes increases the risk and severity of periodontitis, while periodontal inflammation worsens glycaemic control.
Systemic inflammation, driven by cytokines, contributes to complications such as cardiovascular disease and stroke. Associations between severe periodontitis and cardiovascular diseases have also been well-established.
Diabetes mellitus (DM) is a prevalent chronic condition, often undiagnosed, and associated with significant morbidity. Periodontitis is a chronic gum disease linked to systemic inflammation, and dental settings have been proposed as a location for screening undiagnosed DM and prediabetes.
Read more
Periodontitis, a chronic gum disease, involves inflammation and tissue destruction. It is especially common in people living with diabetes, making diagnosis and monitoring crucial.
Read more
Periodontitis has been linked to various systemic diseases, including diabetes, cardiovascular disease, and rheumatoid arthriti
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Partial-mouth protocols (PMPs) are commonly used in population health studies to estimate periodontal disease prevalence, offering a cost-effective and time-efficient alternative to full-mouth protocols (FMPs). However, PMPs are known to underestimate periodontal disease prevalence, which may lead to biases in studies examining associations between periodontitis and systemic conditions like diabetes and cardiovascular disease (CVD).
Read more
Periodontitis, a chronic inflammatory disease caused by bacterial plaque, is associated with systemic conditions such as cardiovascular diseases, diabetes, and adverse pregnancy outcomes. It has also been linked to increased mortality risks
Read more
Periodontal disease, affecting hundreds of millions adults globally, is a leading cause of tooth loss and negatively impacts oral health-related quality of life.
Read more
Inflammation plays a pivotal role in cardiovascular disease (CVD) progression, particularly in patients with diabetes mellitus (DM) and periodontitis, which share risk factors and systemic inflammatory pathways.
Read more
Periodontitis, affecting 11.2% globally, causes tissue destruction, tooth loss, and reduced quality of life. Its bidirectional link with type 2 diabetes mellitus (T2DM) is well-established, with diabetes increasing periodontitis risk and periodontitis worsening glycemic control.
Read more
Periodontitis progression is influenced by common risk factors, including poor oral hygiene, smoking, and lifestyle habits. Interventions targeting these factors can improve treatment outcomes and periodontal health.
Read more
Chronic kidney disease (CKD) involves impaired kidney function, increasing the risk of cardiovascular disease, infection, and mortality. Despite medical advances, CKD prevalence is rising globally.
Read more
Periodontitis and diabetes mellitus (DM) are closely linked, with DM being a significant risk factor for severe periodontitis. Conversely, periodontitis may exacerbate glycaemic management in people living wiith diabetes.
Non-surgical periodontal therapy is an effective treatment to reduce inflammation and improve periodontal health. However, there is uncertainty regarding how diabetes impacts the clinical response to periodontal treatment.
The global rise in type 2 diabetes is a significant contributor to disability and early mortality, often due to vascular and renal complications. Chronic inflammation affects glycaemic control in diabetes, linking it with cardiovascular and kidney diseases. Periodontitis, a prevalent inflammatory condition often co-existing with diabetes, involves an imbalance in oral bacteria and elicits a systemic inflammatory response, raising risks for severe conditions like cardiovascular disease and renal failure. Periodontal therapy aims to manage inflammation through dental cleaning, oral hygiene advice, and possible surgical intervention.
Read more
Diabetes mellitus (DM) is closely associated with periodontitis, with evidence suggesting a bidirectional relationship. While periodontitis may exacerbate systemic inflammation and insulin resistance, periodontal therapy is hypothesised to improve glycaemic management and reduce inflammation in people living with diabetes.
Read more
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterised by insulin resistance and elevated blood glucose levels, influenced by factors like obesity and inflammation.
Read more
Patients with type 2 diabetes mellitus (T2DM) exhibit higher prevalence and severity of chronic periodontitis compared to individuals without diabetes.
Non-surgical periodontal therapy (NSPT), including scaling and root planing (SRP), has been suggested to improve glycaemic control in T2DM patients.
The human microbiome plays a vital role in health, with links between gut microbiota and metabolic disorders like type 2 diabetes mellitus (T2DM).The oral microbiota, particularly the subgingival microbiome, is thought to be influenced by diabetes.
Read more
Gestational diabetes mellitus (GDM) is a carbohydrate intolerance which begins during pregnancy, with Indian women at significantly higher risk (approximately 11-fold) compared to Caucasians.
Read more
Chronic periodontitis is a common inflammatory disease that causes progressive bone loss and, if untreated, can lead to tooth loss.
Read more
Periodontitis is a widespread condition affecting over half of the global adult population, with prevalence increasing with age.Severe periodontitis is one of the most common human diseases, contributing significantly to tooth loss.
Read more
Diabetes mellitus (DM), particularly type 2 (T2DM), is prevalent in the elderly and associated with complications like neuropathy, retinopathy, and cardiovascular issues. Poor glycaemic management exacerbates these complications, significantly affecting quality of life. Periodontitis, a chronic inflammatory disease of the gums, is common in individuals with T2DM. Research indicates a two-way relationship: Periodontitis worsens gum health, while DM elevates systemic inflammation, impairing blood glucose control. In Japan, over half the population aged 40+ years experiences periodontitis. Addressing periodontitis could potentially improve glycaemic management in people with T2DM. This study aimed to assess whether dental visits for periodontal treatment correlate with improved diabetes outcomes in an elderly Japanese cohort.
Read more
There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM). Periodontal disease is more prevalent in those with T2DM and contributes to chronic inflammation, potentially raising HbA1c levels. Persistently high HbA1c can lead to severe complications such as cardiovascular disease, blindness, amputations, renal failure, and premature death.
Read more
Diabetes risk and insulin resistance are associated with chronic systemic inflammation, often exacerbated by microbial factors. Inflammation interferes with insulin signalling, increasing diabetes susceptibility. Periodontitis, a chronic infection of the tooth-supporting structures, is linked to systemic inflammation and glucose intolerance. Emerging research suggests that early microbial changes in the subgingival environment may play a pivotal role in insulin resistance. The study aimed to investigate the relationship between subgingival bacterial composition, systemic inflammation, and insulin resistance in individuals living without diabetes. The hypothesis posited that dysbiosis (bacterial imbalances) in the subgingival microbiome would correlate with elevated inflammation and insulin resistance markers and that systemic inflammation would mediate this relationship. By identifying specific microbial signatures linked to inflammation and glucose regulation, the study hoped to improve early detection of diabetes risks and inform future intervention strategies.
Read more
Chronic kidney disease (CKD) affects 8–13% of the global population and is linked to higher mortality, primarily from cardiovascular disease (CVD).Systemic inflammation is a key non-traditional risk factor in CKD.
Read more
Gestational diabetes mellitus (GDM) and periodontal inflammation are independently associated with adverse pregnancy outcomes, including preterm birth, preeclampsia, and low birth weight.
Read more
Diabetes mellitus (DM) is a significant global health challenge, with Type 2 diabete mellitus (T2DM) often going undiagnosed for years. It is estimated that 46% of diabetes cases worldwide remain undiagnosed, contributing to delayed treatment and increased complications.
Read more
Diabetes mellitus (DM) is a common condition linked to systemic and oral complications, including periodontitis, with evidence of a bidirectional relationship between the two.
Read more
Periodontitis, a chronic inflammatory condition affecting tooth-supporting structures, is increasingly recognised as influencing systemic health. Evidence links periodontitis with cardiovascular disease (CVD), atherosclerosis, and metabolic disorders, such as diabetes. The disease’s systemic effects may stem from persistent low-grade inflammation and the spread of oral bacteria and pro-inflammatory cytokines into circulation. Elevated markers like high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) are shared by periodontitis and atherosclerosis.
Read more
Inflammation plays a pivotal role in cardiovascular disease (CVD) progression, particularly in patients with diabetes mellitus (DM) and periodontitis, which share risk factors and systemic inflammatory pathways.
Read more
Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance and obesity, which increases the risk for cardiovascular diseases and type 2 diabetes. Its prevalence varies globally, influenced by factors such as gender, country, and ethnicity. In the United States, about 25% of adults over 20 and 40% of older adults are affected. In Europe, prevalence ranges from 7% to 36% in men and 5% to 22% in women, depending on the study and population. Rapid economic changes in countries like China have seen a rise in MetS, largely due to increasing obesity rates.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Type 1 Diabetes Mellitus (T1DM) is associated with systemic inflammation, which may worsen oral health. Periodontitis, a chronic inflammatory condition leading to gum and bone loss, has been linked to worse glycaemic control.
Read more
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, leading to progressive periodontal tissue destruction and eventual tooth loss if untreated. The main aetiological factor for periodontitis is plaque. However, the two main risk factors for progression of the disease have been identified as smoking and diabetes.
Read more
Periodontitis is a chronic inflammatory disease affecting tooth-supporting tissues, driven by pathogenic plaque biofilm and a hyper-inflammatory host response. It leads to periodontal pocket formation, tissue destruction, and potential tooth loss. Individuals with Type 2 diabetes face an increased risk and severity of periodontitis due to their predisposition to oxidative stress and inflammation.
Read more
Insulin resistance, a condition where cells fail to respond effectively to insulin, is central to metabolic disorders like type 2 diabetes and cardiovascular disease. It often leads to systemic low-grade inflammation, a feature shared with periodontal disease, suggesting a potential biological link between these conditions.
Read more
Periodontitis and diabetes share a bidirectional relationship, where poor glycaemic control exacerbates periodontal disease and vice versa. The interplay between periodontal inflammation and glycaemic status is mediated by immune cells, primarily T-helper (Th) cells, which regulate pro- and anti-inflammatory cytokine production.
Read more
Periodontal disease and type 2 diabetes mellitus (T2DM) are interrelated, with evidence suggesting that periodontal disease worsens diabetic control and, conversely, that managing periodontal disease can improve glycaemic control. The host inflammatory response plays a key role in increasing susceptibility to periodontal disease, particularly in individuals with systemic conditions like T2DM. Studies show that individuals with severe periodontitis experience more diabetes-related complications and have poorer HbA1c levels over time. The Gullah population of coastal South Carolina and Georgia, descendants of enslaved Africans, is particularly affected by T2DM due to their genetic predisposition and social isolation. The Gullah have a higher prevalence of chronic diseases, including obesity and hypertension, compared to other populations. Notably, periodontal disease is more prevalent among Gullah individuals with T2DM (70.6%) compared to national estimates for African Americans with diabetes (31.3%). This study aimed to explore the relationship between glycaemic control and periodontal disease progression in Gullah individuals with T2DM.
Read more
Diabetes poses a significant public health burden globally, with prevalence expected to rise sharply, especially in urbanizing areas of developing countries.
Read more
Periodontitis, an inflammatory disease causing tissue destruction of the tissues surrounding teeth, may influence systemic inflammation, particularly in individuals with diabetes.
Read more
Periodontitis is the 6th most prevalent condition globally
Periodontitis and diabetes are bidirectionally linked
Diabetic complications are increased if you have both diseases
Successful periodontal treatment can improve blood glucose control
Successful periodontal treatment can improve blood glucose control
Periodontitis is the 6th most prevalent condition globally
Periodontitis and diabetes are bidirectionally linked
Diabetic complications are increased if you have both diseases
Successful periodontal treatment can improve blood glucose control
Successful periodontal treatment can improve blood glucose control
