Research

Vitamin E-related compounds reduced gum damage in laboratory experiments

19.08.23

Researchers are exploring whether gut bacteria influence the substances absorbed into the blood and, in turn, inflammation around teeth. Treated mice showed less loss of bone around teeth and changes in substances controlling bone breakdown.

Cleaning below the gums may modestly improve blood glucose

31.05.23

Periodontal treatment removes deposits from below the gumline to manage inflammation. HbA1c was approximately 0.29 percentage points lower in the treatment groups than in the comparison groups.

A plant compound and gum-cell repair: early diabetes research

20.03.23

Cells need functioning energy-producing structures, called mitochondria, to stay healthy. Some treated rats had less bone loss around teeth and fewer signs of cell damage.

Blood glucose predicted small later changes in gum pockets

19.03.23

The relationship between diabetes and gum disease may operate in both directions. Higher starting HbA1c was associated with slightly deeper gum pockets at follow-up.

Blood sugar management and the health of dental implants

19.02.23

Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that can arise following dental implant placement. These conditions are characterised by inflammation of the peri-implant tissues, which can lead to implant failure if not managed effectively.

One long gum-treatment visit or several shorter visits?

22.01.23

Cleaning below the gumline can be completed in one longer session or over several appointments. Both schedules improved gum health, with no clear difference in the main dental improvements.

Gum treatment helped the gums but did not improve metabolic syndrome

27.08.22

Metabolic syndrome combines several risks, such as raised glucose, blood pressure and changes in blood fats or waist size. Gum treatment substantially improved plaque, bleeding and deep gum pockets.

Healthier gums were linked to a lower chance of developing diabetes

06.07.22

Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of teeth, which can lead to tooth loss and has been associated with various systemic diseases, including diabetes. The relationship between oral health and systemic conditions has garnered increasing attention, particularly as periodontal disease may influence metabolic processes. Previous studies have suggested that individuals with periodontal disease may have a higher risk of developing diabetes due to shared risk factors such as inflammation and insulin resistance.

An inflammation protein may affect bone loss around teeth

30.05.22

C-reactive protein, or CRP, is often measured as a sign of inflammation. Rats lacking CRP had less periodontal bone damage in some experimental comparisons.

Treating gum disease can help with blood sugar management

14.04.22

Diabetes mellitus (DM) is a chronic condition where the body fails to produce or effectively use insulin, resulting in elevated blood glucose. Poor glycaemic control in DM patients can lead to severe complications like cardiovascular disease and kidney failure. The glycosylated haemoglobin assay (HbA1c) is a reliable measure of long-term blood sugar control and is linked to the risk of diabetic complications.

Serum α-tocopherol acetate improves alveolar bone loss in those with diabetes and periodontitis

19.08.23

• Periodontitis, characterised by inflammatory-driven alveolar bone destruction, is exacerbated by diabetes mellitus (DM), which increases inflammatory and pro-osteoclastogenic (formation of bone-resorbing cells) factors in the periodontium.
• Conventional therapies for those with diabetes and periodontitis are limited, necessitating innovative treatments.
• Gut microbiota plays a critical role in regulating inflammation and metabolism, with positive modulation showing potential in alleviating disease.

Subgingival therapy and glycaemic control in type 2 diabetes

31.05.23

There is a well-established bidirectional relationship between periodontitis and diabetes. Individuals with poorly controlled diabetes are at a higher risk of developing periodontal disease due to the effects of hyperglycaemia on immune function and tissue healing. On the other hand, periodontal disease can exacerbate glycaemic control, leading to increased insulin resistance and worsening metabolic outcomes. The systemic inflammation associated with periodontal disease is believed to contribute to the pathophysiology of diabetes, as inflammatory mediators can interfere with insulin signalling pathways.<

PGC-1α activation enhances silibinin’s therapeutic effects in type 1 diabetic periodontitis

20.03.23

• Diabetic periodontitis (DP) is a term used to describe periodontitis influenced by diabetes.
• Diabetes is thought to exacerbate periodontitis through various pathogenic mechanisms, including mitochondrial dysfunction.

An analysis between periodontal condition and glycaemic status

19.03.23

Periodontal disease, a chronic inflammatory condition affecting the supporting structures of teeth, is prevalent among individuals with diabetes, who are often at a heightened risk due to compromised immune responses and metabolic dysregulation. Conversely, poor glycaemic control has been implicated in the progression of periodontal disease, suggesting a bidirectional relationship that warrants further investigation.

Glycaemic control in the prevention of peri-implant diseases

19.02.23

Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that can arise following dental implant placement. These conditions are characterised by inflammation of the peri-implant tissues, which can lead to implant failure if not managed effectively.

Acute-phase response in periodontal treatment in type 2 diabetes

22.01.23

Periodontal treatment involves a stepwise framework, including non-surgical sub-gingival instrumentation as the cornerstone for managing periodontitis. This reduces gingival inflammation, probing pocket depth (PPD), and clinical attachment loss (CAL) while improving overall health and quality of life. However, non-surgical treatment can induce an acute-phase systemic inflammatory reaction post-operatively, including increased acute-phase proteins, endothelial dysfunction, elevated body temperature, clotting tendencies, and renal function reduction.

Periodontal treatment effects on systemic health in patients with metabolic syndrome

27.08.22

Metabolic syndrome (MetS) is a cluster of conditions—obesity, dyslipidemia, hypertension, and insulin resistance—that significantly increase the risk of diabetes and cardiovascular disease.Periodontitis, a chronic inflammatory disease of the gums, has been linked to systemic inflammation, insulin resistance, and worsening glycaemic control.

Improved periodontal health is linked to reduced diabetes risk

06.07.22

Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of teeth, which can lead to tooth loss and has been associated with various systemic diseases, including diabetes. The relationship between oral health and systemic conditions has garnered increasing attention, particularly as periodontal disease may influence metabolic processes. Previous studies have suggested that individuals with periodontal disease may have a higher risk of developing diabetes due to shared risk factors such as inflammation and insulin resistance.

C-reactive protein disrupts alveolar bone balance

30.05.22

Periodontitis, a chronic inflammatory condition, is a leading cause of tooth loss in adults and is exacerbated by diabetes-related hyperglycemia.Diabetes promotes periodontal inflammation and disrupts alveolar bone homeostasis, contributing to tissue damage. Alveolar bone homeostasis involves the endocrine system, signaling interactions between bone and immune cells, and mechanically loaded forces. It relies on bone-resorbing osteoclasts, bone-producing osteoblasts, their precursors and immunoregulatory mediators.

Treating periodontitis can help improve blood sugar control in people with diabetes

14.04.22

Diabetes mellitus (DM) is a chronic condition where the body fails to produce or effectively use insulin, resulting in elevated blood glucose. Poor glycaemic control in DM patients can lead to severe complications like cardiovascular disease and kidney failure. The glycosylated haemoglobin assay (HbA1c) is a reliable measure of long-term blood sugar control and is linked to the risk of diabetic complications.