Research Hub
Welcome to the Research Hub – your go-to source for concise, digestible summaries of the latest research on the connection between periodontitis and diabetes. Explore key findings on topics such as how periodontal inflammation affects glycaemic control and the benefits of periodontal treatment.
Our summaries provide quick insights, but they are not exhaustive. For a complete understanding of each study’s methodology, results, and implications, we encourage you to review the original research articles. Please note that the Periodontitis-Diabetes hub is not responsible for inaccuracies or misinterpretations of condensed content.
For more guidance on understanding research, including how to interpret studies and evaluate their findings, visit the ‘Colgate Professional Website’ and search for ‘Understanding Research in Dentistry.’
Dive into the science and uncover the powerful link between oral and systemic health!
Featured posts
27.05.24
10 mins to read
Background + Aims: Periodontitis affects up to 45% of adults in the United States (US)…
Read more
07.03.24
10 mins to read
Background + Aims: Periodontitis is a chronic inflammatory disease affecting the supporting structures of the…
Read more
11.02.24
10 mins to read
Background + Aims: Prediabetes is increasingly recognised as a major public health issue, affecting about…
Read more
19.02.23
6 mins to read
Background + Aims: Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that…
Read more
06.07.22
5 mins to read
Background + Aims: Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of…
Read more
14.04.22
8 mins to read
Background + Aims: Diabetes mellitus (DM) is a chronic condition where the body fails to…
Read more
14.12.21
7 mins to read
Background + Aims: Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting…
Read more
24.10.18
7 mins to read
Background + Aims: The global rise in type 2 diabetes is a significant contributor to…
Read more
23.06.17
9 mins to read
Background + Aims: There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c)…
Read more
14.08.13
7 mins to read
Background + Aims: Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance…
Read more
27.27.2024
10 mins to read
Background + Aims: Background + Aims Periodontitis affects up to 45% of adults in the United States (US)…
Read more
07.7.2024
10 mins to read
Background + Aims: Background + Aims Periodontitis is a chronic inflammatory disease affecting the supporting structures of the…
Read more
11.11.2024
10 mins to read
Background + Aims: Background + Aims Prediabetes is increasingly recognised as a major public health issue, affecting about…
Read more
19.19.2023
6 mins to read
Background + Aims: Background + Aims Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that…
Read more
06.6.2022
5 mins to read
Background + Aims: Background + Aims Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of…
Read more
14.14.2022
8 mins to read
Background + Aims: Background + Aims Diabetes mellitus (DM) is a chronic condition where the body fails to…
Read more
14.14.2021
7 mins to read
Background + Aims: Background + Aims Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting…
Read more
24.24.2018
7 mins to read
Background + Aims: Background + Aims The global rise in type 2 diabetes is a significant contributor to…
Read more
23.23.2017
9 mins to read
Background + Aims: Background + Aims There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c)…
Read more
14.14.2013
7 mins to read
Background + Aims: Background + Aims Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance…
Read more
05.09.26
In a mouse model of type 2 diabetes, experimentally induced gum disease worsened diabetic nephropathy (DN — kidney damage caused by diabetes) by activating an enzyme–hormone pathway (HPGDS–PGD2) inside the kidney’s filtering units (glomeruli). Blocking this pathway with a drug protected the kidneys. A small clinical study in patients suggested a possible link between urinary HPGDS, kidney function and gum disease.
Read more
15.03.26
This study in mice found that diabetes-related changes in gut bacteria weakened the gut’s protective lining and increased oxidative stress, worsening gum inflammation and bone loss. Restoring healthier gut bacteria, protecting the gut lining or giving oleic acid reduced this damage, but studies in people are needed to confirm these benefits.
Read more
22.12.25
Periodontitis is associated with systemic inflammation and has been linked to chronic kidney disease and diabetes. This randomised trial examined whether non-surgical periodontal treatment improves kidney function, systemic inflammation and blood glucose control in patients with chronic kidney disease.
Read more
13.10.25
A combination of bacteria and inflammatory markers in saliva distinguished participants with type 2 diabetes and periodontitis from systemically healthy participants without periodontitis, with reported accuracy of 95%. Further testing is needed to establish whether it can reliably identify gum disease within the diabetic population.
Read more
22.09.25
In mice, butyrate (a substance produced by gut bacteria) reduced diabetes-associated periodontal damage and restored the balance between two types of immune cells. Whether this approach benefits people remains unproven.
Read more
17.09.25
Adding Limosilactobacillus reuteri probiotics to periodontal treatment did not provide additional improvements in gum health or overall bacterial outcomes in patients with diabetes. A possible improvement in blood glucose control was observed, but it was not statistically significant in a separate analysis excluding participants with protocol deviations.
Read more
27.08.25
In a large Swedish register-based study of nearly 19,000 people with dental implants, both type 1 diabetes (T1DM) and type 2 diabetes (T2DM) were associated with a higher risk of peri-implantitis (inflammation and progressive bone loss around a dental implant). The link was clearest for T1DM, particularly when blood-sugar control was poor.
Read more
04.08.25
In diabetic mice, oxidative stress (an imbalance between damaging free radicals and the body’s antioxidant defences) and gut dysbiosis (an unhealthy shift in gut bacteria) appear to fuel each other, worsening periodontitis (inflammatory destruction of the tissues supporting the teeth). Both an antioxidant (curcumin) and faecal microbiota transplantation (FMT — transfer of stool bacteria from a healthy donor) reduced this damage.
Read more
17.06.25
In a mouse model of type 2 diabetes, experimentally induced gum disease worsened diabetic nephropathy (DN — kidney damage caused by diabetes) by activating an enzyme–hormone pathway (HPGDS–PGD2) inside the kidney’s filtering units (glomeruli). Blocking this pathway with a drug protected the kidneys. A small clinical study in patients suggested a possible link between urinary HPGDS, kidney function and gum disease.
Read more
12.05.25
In 43 patients with metabolic syndrome, a 5–10-day medically supervised prolonged fast was associated with lower gum inflammation, less plaque and small, selective shifts in oral bacteria. The overall oral microbiome remained largely stable.
Read more
Research Hub
Welcome to the Research Hub – your go-to source for concise, digestible summaries of the latest research on the connection between periodontitis and diabetes. Explore key findings on topics such as how periodontal inflammation affects glycaemic control and the benefits of periodontal treatment.
Our summaries provide quick insights, but they are not exhaustive. For a complete understanding of each study’s methodology, results, and implications, we encourage you to review the original research articles. Please note that the Periodontitis-Diabetes hub is not responsible for inaccuracies or misinterpretations of condensed content.
For more guidance on understanding research, including how to interpret studies and evaluate their findings, visit the ‘Colgate Professional Website’ and search for ‘Understanding Research in Dentistry.’
Dive into the science and uncover the powerful link between oral and systemic health!
Featured posts
27.05.24
10 mins to read
Background + Aims: Periodontitis affects up to 45% of adults in the United States (US)…
Read more
07.03.24
10 mins to read
Background + Aims: Periodontitis is a chronic inflammatory disease affecting the supporting structures of the…
Read more
11.02.24
10 mins to read
Background + Aims: Prediabetes is increasingly recognised as a major public health issue, affecting about…
Read more
19.02.23
6 mins to read
Background + Aims: Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that…
Read more
06.07.22
5 mins to read
Background + Aims: Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of…
Read more
14.04.22
8 mins to read
Background + Aims: Diabetes mellitus (DM) is a chronic condition where the body fails to…
Read more
14.12.21
7 mins to read
Background + Aims: Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting…
Read more
24.10.18
7 mins to read
Background + Aims: The global rise in type 2 diabetes is a significant contributor to…
Read more
23.06.17
9 mins to read
Background + Aims: There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c)…
Read more
14.08.13
7 mins to read
Background + Aims: Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance…
Read more
27.27.2024
10 mins to read
Background + Aims: Background + Aims Periodontitis affects up to 45% of adults in the United States (US)…
Read more
07.7.2024
10 mins to read
Background + Aims: Background + Aims Periodontitis is a chronic inflammatory disease affecting the supporting structures of the…
Read more
11.11.2024
10 mins to read
Background + Aims: Background + Aims Prediabetes is increasingly recognised as a major public health issue, affecting about…
Read more
19.19.2023
6 mins to read
Background + Aims: Background + Aims Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that…
Read more
06.6.2022
5 mins to read
Background + Aims: Background + Aims Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of…
Read more
14.14.2022
8 mins to read
Background + Aims: Background + Aims Diabetes mellitus (DM) is a chronic condition where the body fails to…
Read more
14.14.2021
7 mins to read
Background + Aims: Background + Aims Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting…
Read more
24.24.2018
7 mins to read
Background + Aims: Background + Aims The global rise in type 2 diabetes is a significant contributor to…
Read more
23.23.2017
9 mins to read
Background + Aims: Background + Aims There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c)…
Read more
14.14.2013
7 mins to read
Background + Aims: Background + Aims Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance…
Read more
05.09.26
In a mouse model of type 2 diabetes, experimentally induced gum disease worsened diabetic nephropathy (DN — kidney damage caused by diabetes) by activating an enzyme–hormone pathway (HPGDS–PGD2) inside the kidney’s filtering units (glomeruli). Blocking this pathway with a drug protected the kidneys. A small clinical study in patients suggested a possible link between urinary HPGDS, kidney function and gum disease.
Read more
15.03.26
This study in mice found that diabetes-related changes in gut bacteria weakened the gut’s protective lining and increased oxidative stress, worsening gum inflammation and bone loss. Restoring healthier gut bacteria, protecting the gut lining or giving oleic acid reduced this damage, but studies in people are needed to confirm these benefits.
Read more
22.12.25
Periodontitis is associated with systemic inflammation and has been linked to chronic kidney disease and diabetes. This randomised trial examined whether non-surgical periodontal treatment improves kidney function, systemic inflammation and blood glucose control in patients with chronic kidney disease.
Read more
13.10.25
A combination of bacteria and inflammatory markers in saliva distinguished participants with type 2 diabetes and periodontitis from systemically healthy participants without periodontitis, with reported accuracy of 95%. Further testing is needed to establish whether it can reliably identify gum disease within the diabetic population.
Read more
22.09.25
In mice, butyrate (a substance produced by gut bacteria) reduced diabetes-associated periodontal damage and restored the balance between two types of immune cells. Whether this approach benefits people remains unproven.
Read more
17.09.25
Adding Limosilactobacillus reuteri probiotics to periodontal treatment did not provide additional improvements in gum health or overall bacterial outcomes in patients with diabetes. A possible improvement in blood glucose control was observed, but it was not statistically significant in a separate analysis excluding participants with protocol deviations.
Read more
27.08.25
In a large Swedish register-based study of nearly 19,000 people with dental implants, both type 1 diabetes (T1DM) and type 2 diabetes (T2DM) were associated with a higher risk of peri-implantitis (inflammation and progressive bone loss around a dental implant). The link was clearest for T1DM, particularly when blood-sugar control was poor.
Read more
04.08.25
In diabetic mice, oxidative stress (an imbalance between damaging free radicals and the body’s antioxidant defences) and gut dysbiosis (an unhealthy shift in gut bacteria) appear to fuel each other, worsening periodontitis (inflammatory destruction of the tissues supporting the teeth). Both an antioxidant (curcumin) and faecal microbiota transplantation (FMT — transfer of stool bacteria from a healthy donor) reduced this damage.
Read more
17.06.25
In a mouse model of type 2 diabetes, experimentally induced gum disease worsened diabetic nephropathy (DN — kidney damage caused by diabetes) by activating an enzyme–hormone pathway (HPGDS–PGD2) inside the kidney’s filtering units (glomeruli). Blocking this pathway with a drug protected the kidneys. A small clinical study in patients suggested a possible link between urinary HPGDS, kidney function and gum disease.
Read more
12.05.25
In 43 patients with metabolic syndrome, a 5–10-day medically supervised prolonged fast was associated with lower gum inflammation, less plaque and small, selective shifts in oral bacteria. The overall oral microbiome remained largely stable.
Read more
Research Hub
Welcome to the Research Hub – your go-to source for concise, digestible summaries of the latest research on the connection between periodontitis and diabetes. Explore key findings on topics such as how periodontal inflammation affects glycaemic control and the benefits of periodontal treatment.
Our summaries provide quick insights, but they are not exhaustive. For a complete understanding of each study’s methodology, results, and implications, we encourage you to review the original research articles. Please note that the Periodontitis-Diabetes hub is not responsible for inaccuracies or misinterpretations of condensed content.
For more guidance on understanding research, including how to interpret studies and evaluate their findings, visit the ‘Colgate Professional Website’ and search for ‘Understanding Research in Dentistry.’
Dive into the science and uncover the powerful link between oral and systemic health!
Featured posts
27.05.24
10 mins to read
Background + Aims: Periodontitis affects up to 45% of adults in the United States (US)…
Read more
07.03.24
10 mins to read
Background + Aims: Periodontitis is a chronic inflammatory disease affecting the supporting structures of the…
Read more
11.02.24
10 mins to read
Background + Aims: Prediabetes is increasingly recognised as a major public health issue, affecting about…
Read more
19.02.23
6 mins to read
Background + Aims: Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that…
Read more
06.07.22
5 mins to read
Background + Aims: Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of…
Read more
14.04.22
8 mins to read
Background + Aims: Diabetes mellitus (DM) is a chronic condition where the body fails to…
Read more
14.12.21
7 mins to read
Background + Aims: Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting…
Read more
24.10.18
7 mins to read
Background + Aims: The global rise in type 2 diabetes is a significant contributor to…
Read more
23.06.17
9 mins to read
Background + Aims: There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c)…
Read more
14.08.13
7 mins to read
Background + Aims: Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance…
Read more
27.27.2024
10 mins to read
Background + Aims: Background + Aims Periodontitis affects up to 45% of adults in the United States (US)…
Read more
07.7.2024
10 mins to read
Background + Aims: Background + Aims Periodontitis is a chronic inflammatory disease affecting the supporting structures of the…
Read more
11.11.2024
10 mins to read
Background + Aims: Background + Aims Prediabetes is increasingly recognised as a major public health issue, affecting about…
Read more
19.19.2023
6 mins to read
Background + Aims: Background + Aims Peri-implant diseases (PIDs), including peri-implant mucositis and peri-implantitis, are significant complications that…
Read more
06.6.2022
5 mins to read
Background + Aims: Background + Aims Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of…
Read more
14.14.2022
8 mins to read
Background + Aims: Background + Aims Diabetes mellitus (DM) is a chronic condition where the body fails to…
Read more
14.14.2021
7 mins to read
Background + Aims: Background + Aims Periodontitis is a chronic inflammatory disease leading to the destruction of tooth-supporting…
Read more
24.24.2018
7 mins to read
Background + Aims: Background + Aims The global rise in type 2 diabetes is a significant contributor to…
Read more
23.23.2017
9 mins to read
Background + Aims: Background + Aims There is increasing evidence linking periodontal inflammation to elevated glycated haemoglobin (HbA1c)…
Read more
14.14.2013
7 mins to read
Background + Aims: Background + Aims Metabolic syndrome (MetS) is a cluster of risk factors, including insulin resistance…
Read more
05.09.26
In a mouse model of type 2 diabetes, experimentally induced gum disease worsened diabetic nephropathy (DN — kidney damage caused by diabetes) by activating an enzyme–hormone pathway (HPGDS–PGD2) inside the kidney’s filtering units (glomeruli). Blocking this pathway with a drug protected the kidneys. A small clinical study in patients suggested a possible link between urinary HPGDS, kidney function and gum disease.
Read more
15.03.26
This study in mice found that diabetes-related changes in gut bacteria weakened the gut’s protective lining and increased oxidative stress, worsening gum inflammation and bone loss. Restoring healthier gut bacteria, protecting the gut lining or giving oleic acid reduced this damage, but studies in people are needed to confirm these benefits.
Read more
22.12.25
Periodontitis is associated with systemic inflammation and has been linked to chronic kidney disease and diabetes. This randomised trial examined whether non-surgical periodontal treatment improves kidney function, systemic inflammation and blood glucose control in patients with chronic kidney disease.
Read more
13.10.25
A combination of bacteria and inflammatory markers in saliva distinguished participants with type 2 diabetes and periodontitis from systemically healthy participants without periodontitis, with reported accuracy of 95%. Further testing is needed to establish whether it can reliably identify gum disease within the diabetic population.
Read more
22.09.25
In mice, butyrate (a substance produced by gut bacteria) reduced diabetes-associated periodontal damage and restored the balance between two types of immune cells. Whether this approach benefits people remains unproven.
Read more
17.09.25
Adding Limosilactobacillus reuteri probiotics to periodontal treatment did not provide additional improvements in gum health or overall bacterial outcomes in patients with diabetes. A possible improvement in blood glucose control was observed, but it was not statistically significant in a separate analysis excluding participants with protocol deviations.
Read more
27.08.25
In a large Swedish register-based study of nearly 19,000 people with dental implants, both type 1 diabetes (T1DM) and type 2 diabetes (T2DM) were associated with a higher risk of peri-implantitis (inflammation and progressive bone loss around a dental implant). The link was clearest for T1DM, particularly when blood-sugar control was poor.
Read more
04.08.25
In diabetic mice, oxidative stress (an imbalance between damaging free radicals and the body’s antioxidant defences) and gut dysbiosis (an unhealthy shift in gut bacteria) appear to fuel each other, worsening periodontitis (inflammatory destruction of the tissues supporting the teeth). Both an antioxidant (curcumin) and faecal microbiota transplantation (FMT — transfer of stool bacteria from a healthy donor) reduced this damage.
Read more
17.06.25
In a mouse model of type 2 diabetes, experimentally induced gum disease worsened diabetic nephropathy (DN — kidney damage caused by diabetes) by activating an enzyme–hormone pathway (HPGDS–PGD2) inside the kidney’s filtering units (glomeruli). Blocking this pathway with a drug protected the kidneys. A small clinical study in patients suggested a possible link between urinary HPGDS, kidney function and gum disease.
Read more
12.05.25
In 43 patients with metabolic syndrome, a 5–10-day medically supervised prolonged fast was associated with lower gum inflammation, less plaque and small, selective shifts in oral bacteria. The overall oral microbiome remained largely stable.
Read more
