Diabetes mellitus exacerbates inflammation in a murine model of ligature-induced peri-implantitis: A histological and microtomographic study
(Journal of Clinical Periodontology; doi: 10.1111/jcpe.14051)
Davi N A Silva, Sepehr Monajemzadeh, Maísa Casarin, Jaclyn Chalmers, Jacob Lubben, Clara E Magyar, Sotirios Tetradis, Flavia Q Pirih
Some people with diabetes experience problems with the tissues around dental implants. This experiment investigated possible changes in inflammation and tissue breakdown that might help explain the connection.
Twenty-seven male mice received implants. Researchers compared healthy conditions, experimentally induced inflammation around implants, and the same inflammation with induced diabetes. They examined bone scans, inflammatory cells and proteins involved in tissue maintenance.
Mice with diabetes and implant inflammation lost more supporting bone than mice with inflammation alone. They also had more bone-removing cells and disrupted collagen, a structural component of connective tissue. Levels of some tissue-breakdown proteins increased, while one regulating protein decreased. Measuring these protein levels did not directly prove how active the enzymes were.
This provides a possible explanation for impaired tissue health around implants, not a prediction that an implant will fail in someone with diabetes. The implants and short disease period differed from normal human dental care, and only small numbers of tissue samples were examined. The study tested a mechanism, not a treatment. Personal implant planning still needs an assessment of your mouth, diabetes and other relevant factors.
Animal and laboratory studies allow researchers to investigate processes that cannot easily be tested in people. However, experimentally induced diabetes or gum damage does not reproduce every aspect of human disease. The timing, exposure and biological responses may differ substantially. A promising effect in this setting needs further testing for both benefit and harm before it can inform patient treatment. This paper therefore helps explain a possible mechanism; it does not establish an effective human treatment or a safe dose of an experimental substance.
Read the full article Back to Research
Periodontitis is the 6th most prevalent condition globally
Periodontitis and diabetes are bidirectionally linked
Diabetic complications are increased if you have both diseases
Successful periodontal treatment can improve blood glucose control
Periodontitis is the 6th most prevalent condition globally
Periodontitis and diabetes are bidirectionally linked
Diabetic complications are increased if you have both diseases
Successful periodontal treatment can improve blood glucose control
