Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes
(Journal of Clinical Periodontology; doi: 10.1111/j.1600-051X.2009.01498.x)
Fernanda O B Correa, Daniela Gonçalves, Carlos M S Figueredo, Alliny S Bastos, Anders Gustafsson, Silvana R P Orrico
Dental treatment can be successful even when blood glucose does not improve. Researchers examined whether changes in gum health after treatment were accompanied by changes in glucose and inflammation in type 2 diabetes.
Twenty-three adults with type 2 diabetes and periodontitis in Brazil received cleaning below the gums across four sessions, with oral hygiene support and regular plaque control. Gum examinations and blood tests were repeated after three months. There was no untreated comparison group.
Plaque, bleeding, pocket depth and measurements of tooth support improved. Levels of TNF-alpha, an inflammatory protein, and fibrinogen, a protein involved in clotting and inflammation, decreased. Other inflammatory markers did not show statistically clear reductions. Neither HbA1c nor fasting glucose improved significantly. Changes in the blood markers did not clearly correlate with the changes in gum measurements.
The study supports the value of assessing dental and diabetes outcomes separately. Better gum health is a meaningful result even if HbA1c remains unchanged. Reductions in particular blood proteins do not prove that diabetes complications or cardiovascular events have been prevented. Because the study was small and lacked a comparison group, it cannot establish the size of any wider treatment benefit. It should be read alongside larger controlled studies when considering effects on diabetes.
Changes seen during a study need careful interpretation. Without a comparable group receiving a different approach, it is difficult to separate an intervention from natural variation or other changes happening at the same time. Repeated measurements can describe a response, but cannot by themselves establish its cause. Laboratory markers also do not necessarily predict long-term symptoms, tooth retention or diabetes complications. The findings are useful for generating questions and understanding possible responses, while larger, well-controlled studies help establish the benefits patients can expect.
Read the full article Back to ResearchHosted by #diabeteschat, join Dr Varkha Rattu and the team behind the Periodontitis-Diabetes Hub for an insightful discussion exploring the importance of managing periodontitis and diabetes.
Read moreDr Antoniszczak will present a lecture about the oral health challenges among people living with diabetes. This lecture explores the key challenges faced by individuals living with diabetes, focusing on…
Read moreHosted by #diabeteschat, join Dr Varkha Rattu and the team behind the Periodontitis-Diabetes Hub for an insightful discussion exploring the importance of managing periodontitis and diabetes.
Read moreDr Antoniszczak will present a lecture about the oral health challenges among people living with diabetes. This lecture explores the key challenges faced by individuals living with diabetes, focusing on the relationship between diabetes and oral health.
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