Treatment of periodontitis reduces systemic inflammation in type 2 diabetes.
(Journal of Clinical Periodontology; doi: 10.1111/jcpe.13274)
Philip M. Preshaw, John J. Taylor, Katrin M. Jaedicke, Marko De Jager, Jan Willem Bikker, Wieke Selten, Susan M. Bissett, Kerry M. Whall, Rachel van de Merwe, Aisha Areibi, Paiboon Jitprasertwong, Rana Al-Shahwani, Jolanta Weaver, Roy Taylor, Rebecca R. Wassall
Inflammation can be measured locally in the gums and more broadly in the blood. Researchers examined whether these responses changed after periodontal treatment in people with and without type 2 diabetes.
The study included eighty-three participants with diabetes and seventy-five comparison participants without it. People with periodontitis received non-surgical treatment and follow-up care. Researchers measured gum health and selected inflammatory substances over twelve months.
Gum measurements improved after treatment, and several markers in the fluid around teeth decreased. Statistical modelling suggested a reduction in wider inflammation, with a stronger change in the diabetes group. Changes in inflammation alone should not be taken to mean that blood glucose necessarily improved.
The clearest message is that gum treatment was followed by better local gum health in both groups. Changes in inflammatory markers may help explain biological links, but they do not demonstrate fewer diabetes complications. Participants were recruited differently and treatment was not randomly allocated, which complicates comparisons. The findings do not establish a predictable blood glucose benefit for an individual patient.
Changes seen during a study need careful interpretation. Without a comparable group receiving a different approach, it is difficult to separate an intervention from natural variation or other changes happening at the same time. Repeated measurements can describe a response, but cannot by themselves establish its cause. Laboratory markers also do not necessarily predict long-term symptoms, tooth retention or diabetes complications. The findings are useful for generating questions and understanding possible responses, while larger, well-controlled studies help establish the benefits patients can expect.
Read the full article Back to ResearchHosted by #diabeteschat, join Dr Varkha Rattu and the team behind the Periodontitis-Diabetes Hub for an insightful discussion exploring the importance of managing periodontitis and diabetes.
Read moreDr Antoniszczak will present a lecture about the oral health challenges among people living with diabetes. This lecture explores the key challenges faced by individuals living with diabetes, focusing on…
Read moreHosted by #diabeteschat, join Dr Varkha Rattu and the team behind the Periodontitis-Diabetes Hub for an insightful discussion exploring the importance of managing periodontitis and diabetes.
Read moreDr Antoniszczak will present a lecture about the oral health challenges among people living with diabetes. This lecture explores the key challenges faced by individuals living with diabetes, focusing on the relationship between diabetes and oral health.
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