Gum treatment and inflammation in people with type 2 diabetes

Summarised from:

Treatment of periodontitis reduces systemic inflammation in type 2 diabetes.
(Journal of Clinical Periodontology; doi: 10.1111/jcpe.13274)

Authors:

Philip M. Preshaw, John J. Taylor, Katrin M. Jaedicke, Marko De Jager, Jan Willem Bikker, Wieke Selten, Susan M. Bissett, Kerry M. Whall, Rachel van de Merwe, Aisha Areibi, Paiboon Jitprasertwong, Rana Al-Shahwani, Jolanta Weaver, Roy Taylor, Rebecca R. Wassall

Summarised by:

Dr Varkha Rattu

Research Topic:

Why does this matter?

Inflammation can be measured locally in the gums and more broadly in the blood. Researchers examined whether these responses changed after periodontal treatment in people with and without type 2 diabetes.

What was studied?

The study included eighty-three participants with diabetes and seventy-five comparison participants without it. People with periodontitis received non-surgical treatment and follow-up care. Researchers measured gum health and selected inflammatory substances over twelve months.

What did the researchers find?

Gum measurements improved after treatment, and several markers in the fluid around teeth decreased. Statistical modelling suggested a reduction in wider inflammation, with a stronger change in the diabetes group. Changes in inflammation alone should not be taken to mean that blood glucose necessarily improved.

What does this mean for me?

The clearest message is that gum treatment was followed by better local gum health in both groups. Changes in inflammatory markers may help explain biological links, but they do not demonstrate fewer diabetes complications. Participants were recruited differently and treatment was not randomly allocated, which complicates comparisons. The findings do not establish a predictable blood glucose benefit for an individual patient.

What should I keep in mind?

Changes seen during a study need careful interpretation. Without a comparable group receiving a different approach, it is difficult to separate an intervention from natural variation or other changes happening at the same time. Repeated measurements can describe a response, but cannot by themselves establish its cause. Laboratory markers also do not necessarily predict long-term symptoms, tooth retention or diabetes complications. The findings are useful for generating questions and understanding possible responses, while larger, well-controlled studies help establish the benefits patients can expect.

Read the full article Back to Research

Research  |  27.02.20

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Periodontitis is the 6th most prevalent condition globally

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Periodontitis and diabetes are bidirectionally linked

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Diabetic complications are increased if you have both diseases

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Team - The Periodontitis-Diabetes Hub

Dr Varkha Rattu

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Diabetes Co-Lead

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Diabetes Co-Lead

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Team - The Periodontitis-Diabetes Hub

Dr Varkha Rattu

Periodontitis-Diabetes Hub Position: Founder & Periodontology Co-Lead

Team - The Periodontitis-Diabetes Hub

Dr Amar Puttanna

Periodontitis-Diabetes Hub Position: Diabetes Co-Lead

Team - The Periodontitis-Diabetes Hub

Dr Rajeev Raghavan

Periodontitis-Diabetes Hub Position: Diabetes Co-Lead

Team - The Periodontitis-Diabetes Hub

Professor Mark Ide

Periodontitis-Diabetes Hub Position: Periodontology Co-Lead

Team - The Periodontitis-Diabetes Hub

Professor Luigi Nibali

Periodontitis-Diabetes Hub Position: Periodontology Co-Lead

Team - The Periodontitis-Diabetes Hub

Dr Dominika Antoniszczak

Periodontitis-Diabetes Hub Position: Education and Support Advisor

Team - The Periodontitis-Diabetes Hub

Dr Jasmine Loke

Periodontitis-Diabetes Hub Position: Clinical Content Advisor

Team - The Periodontitis-Diabetes Hub

Dr Mira Shah

Periodontitis-Diabetes Hub Position: Patient Resource Advisor

Team - The Periodontitis-Diabetes Hub

Elaine Tilling

Periodontitis-Diabetes Hub Position: Outreach and Communications Lead

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