Glomerular Haematopoietic Prostaglandin D Synthase-Prostaglandin D2 Axis Contributes to the Periodontitis-Related Exacerbation of Diabetic Nephropathy in KK-Ay Mice
(Journal of Clinical Periodontology; doi: 10.1111/jcpe.14180)
Kohei Sato, Takanori Shinjo, Tatsuro Zeze, Al-Kafee Ahmed, Honoka Otsuka, Hisashi Yokomizo, Naoichi Sato, Mio Imagawa, Yuki Nishimura, Naoaki Ryo, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Misaki Iwashita, Fusanori Nishimura
People with diabetes can develop kidney problems, and researchers are investigating whether inflammation elsewhere in the body contributes.
This study explored one possible biological link between gum disease and kidney damage.
Most experiments were in mice with a type 2 diabetes-like condition.
Researchers induced gum inflammation, measured kidney injury and tested a compound that blocks an inflammation-related enzyme.
A separate exploratory comparison involved only twelve people with type 2 diabetes.
Gum inflammation worsened kidney injury in the diabetic mice without raising their blood glucose.
Blocking the enzyme improved several kidney measurements but did not improve gum bone loss or blood glucose.
In the small human group, an enzyme measurement in urine was linked to deeper gum pockets. That finding does not establish the same mechanism or treatment effect in people.
The study helps researchers decide which pathways to investigate next. It does not show that the experimental compound is a suitable medicine for patients or that treating gum disease prevents kidney failure. If you have diabetes and kidney disease, this research should not change your prescribed care. Its main value is explaining a possible connection that needs much more testing.
Animal and laboratory studies allow researchers to investigate processes that cannot easily be tested in people. However, experimentally induced diabetes or gum damage does not reproduce every aspect of human disease. The timing, exposure and biological responses may differ substantially. A promising effect in this setting needs further testing for both benefit and harm before it can inform patient treatment. This paper therefore helps explain a possible mechanism; it does not establish an effective human treatment or a safe dose of an experimental substance.
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Periodontitis is the 6th most prevalent condition globally
Periodontitis and diabetes are bidirectionally linked
Diabetic complications are increased if you have both diseases
Successful periodontal treatment can improve blood glucose control
Periodontitis is the 6th most prevalent condition globally
Periodontitis and diabetes are bidirectionally linked
Diabetic complications are increased if you have both diseases
Successful periodontal treatment can improve blood glucose control
